Inclusion Chemistry of Flexible Hosts

是由无机，生物无机和有机- 金属计划，以教授杰里阿特伍德的大学 亚拉巴马州将继续资助宾主化学的研究 涉及杯芳烃。 杯芳烃是灵活的大环化合物 （宿主）可以将较小的分子（客人）与 多个非共价相互作用。 重点将放在：1） 与金属络合物作为第一和第二球的相互作用 配体，2）在配体的疏水腔中包含水， 水溶性杯[4]！芳烃，3）构象和络合 高（n=5-8）calixın！芳烃，和4）进一步 发现的双层固态结构的表征 calizı4！芳烃磺酸盐和相关化合物。 信息 从这些关于宾主关系性质的研究中获得的 相互作用将影响分离科学和生物学 化学. %%% 这项研究将为我们提供重要的基础知识。 关于多个但高度特异性非共价 分子间的相互作用。 这种互动是负责任的 用于生物系统中酶识别底物 并允许分离非常相似的混合物 分子时，可以设计适当的宿主， 合成了

is award from the Inorganic, Bioinorganic and Organo- metallic Program to Professor Jerry Atwood of the University of Alabama will fund continued studies of guest-host chemistry involving calixarenes. Calixarenes are flexible, macrocycles (hosts) that can incorporate smaller molecules (guests) with multiple non-covalent interactions. Emphasis will be on: 1) interactions with metal complexes as primary and second sphere ligands, 2) inclusion of water in the hydrophobic cavity of water soluble calixı4!arenes, 3) conformation and complexation of higher (n=5-8) calixın!arenes, and 4) further characterization of bilayer solid state structures found for calizı4!arene sulfonates and related compounds. Information obtained from these studies on the nature of guest-host interactions will impact on separation science and biological chemistry. %%% This study is expected to provide important fundamental information about multiple, but highly specific, non-covalent interactions of molecules. Such interactions are responsible for recognition of substrates by enzymes in biological systems and allow for the separation of mixtures of very similar molecules when appropriate hosts can be designed and synthesized.