STC Center in Microbial Ecology

密歇根州立大学（MSU）的这项提案要求资金 建立微生物科学技术中心 生态 该中心的主任将是詹姆斯M教授。 蒂杰 为了实现中心的目标， 围绕三个关键领域的知识： 生物体，这些生物体的生理能力， 环境对这些生物的影响。 该中心是 旨在对未解之谜产生最大的影响 对理解生物体的成功和功能很重要 在他们的栖息地。 研究计划将根据选定的组成部分组织 这三个关键领域的项目。 的项目 将是基因库的可及性，种群多样性，社区 多样性，新生物，底物利用率，环境 控制、粘附、天然毒素、化学分析和DNA 探测方法学 每一个都有明确的研究 范围包括短期目标（3-5年）和长期目标 目标（10-11年）。 各个项目在 有很多方法来促进对更广泛问题的理解。 项目交互的一个例子是 开发生物降解危险废物的新工艺。 这 要求提供关于新型脱氯生物及其 与自然隔离（新生物），以及是否关键 基因可以在这些不寻常的生物体中扩增或转移， 或需要新的载体开发（基因库可访问性）。 对这些生物体的利用可能需要它们 保留（粘附力），并且该过程应按顺序降解 副产品（环境控制）。 在其所有研究中，该中心将以基本原则为基础， 整合相关学科资源， 特殊问题。 来自工业界和其他联邦机构的资金将 将这些原则转化为非常有用的技术。

This proposal from Michigan State University (MSU) requests funds to establish a Science and Technology Center in Microbial Ecology. The Director of the Center will be Professor James M. Tiedje. To achieve the goal of the Center the research has been organized around three key areas of knowledge: the genetic features of organisms, the physiological capacity of these organisms, and the effect of the environment on these organisms. The Center is intended to make the greatest impact on the unanswered questions important to understanding the success and function of organisms in their habitat. The research program will be organized under selected component projects that contribute to the three key areas. The projects will be gene pool accessibility, population diversity, community diversity, novel organisms, substrate availability, environmental control, adhesion, natural toxins, chemical analysis, and DNA probe methodology. Each of these has a well defined research scope consisting of short term goals (3-5 years) and longer range objectives (10-11 years). The individual projects interact in many ways to advance understanding of broader issues. An example of the project interaction is the problem of developing new processes to biodegrade hazardous wastes. This requires information on novel dechlorinating organisms and their isolation from nature (Novel Organisms), and on whether critical genes can be amplified or transferred in these unusual organisms, or requires novel vector development (Gene Pool Accessibility). The exploitation of these organisms may require that they be retained (Adhesion), and that the process be sequenced to degrade byproducts (Environmental Control). In all of its research the Center will build on basic principles, drawing together the relevant disciplinary resources to solve particular problems. Funding from industry as well as other Federal agencies will then translate these principles into highly useful technology.