Center for Microbial Pathogenesis and Host Inflammatory Responses

项目总结/摘要 微生物发病机制和宿主炎症反应中心（CMPHIR：P20-GM 103625） 2012年在阿肯色州医学科学大学（UAMS）成立。潜在的科学主题 以临床相关的方式解决传染病中现有的和新出现的问题将需要 了解病原体本身以及它们如何影响宿主的免疫功能， 炎症反应。这个主题是基于这样一个前提，即理解 不同的病原体和它们共同的人类宿主是最大限度地利用机会的先决条件。 该等式的一侧或两侧有利于期望的预防和/或治疗结果。第一阶段 第二，我们围绕这一科学主题召集了大量的调查人员，并为他们提供了 他们需要行政和技术资源来建立成功的科学事业。在第三阶段，我们 我们将完善和扩大这些努力，总体目标是在第一阶段和第二阶段取得成功的基础上， 建立一个自我维持的生物医学研究卓越中心，专注于传染病， 全面和临床相关的方式。为此，第三阶段申请的具体目标是： 1)提供基础设施，通过支持CMPHIR调查人员的竞争力最大化 2）促进CMPHIR的持续发展和其调查人员的职业发展; 3）将CMPHIR转变为国家认可的自我维持的生物医学研究中心 卓越的专业知识和资源，以解决现有的和新出现的传染病问题。

PROJECT SUMMARY/ABSTRACT The Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR: P20-GM103625) was established at the University of Arkansas for Medical Sciences (UAMS) in 2012. The underlying scientific theme is that addressing existing and emerging problems in infectious disease in a clinically relevant fashion will require an understanding of both the pathogens themselves and how they impact the host immunological and inflammatory response. This theme is based on the premise that understanding the complex interplay between diverse pathogens and their common human host is a prerequisite to maximizing opportunities to manipulate one or both sides of this equation in favor of the desired prophylactic and/or therapeutic outcome. In Phases I and II, we assembled a critical mass of investigators around this scientific theme and provided them with the administrative and technical resources they needed to establish successful scientific careers. In Phase III, we will refine and expand on these efforts with the overall goal of building on our success in Phases I and II to establish a self-sustaining Center of Biomedical Research Excellence that focuses on infectious diseases in a comprehensive and clinically relevant fashion. To this end, the specific aims of this Phase III application are to: 1) provide an infrastructure that maximizes the competitiveness of CMPHIR investigators through the support of essential core facilities; 2) promote continued growth of the CMPHIR and career development of its investigators; and 3) transition the CMPHIR to a nationally recognized, self-sustaining Center of Biomedical Research Excellence with the expertise and resources to address existing and emerging problems in infectious disease.