Collaborative Microbial Metabolite Center

项目摘要/摘要 我们的饮食、微生物新陈代谢和下游生物效应之间的相互作用 在主机上有关键的基础知识，将指导精准医学一体化的发展 有营养的。为了表征这些从食物或食物转化而来的个体代谢物的功能 微生物组的完全合成将提高对微生物-饮食-宿主机制的理解 互动。尽管这很重要，但社区缺乏一个集中的知识管理中心 并聚集了这些代谢物的生物活性和功能，阻碍了研究人员重新利用 以高吞吐量的方式获取知识，并建立在他人发现的基础上。建议的“协作” 这里提出的微生物代谢物中心或CMMC将填补科学图景中的这一空白，旨在 整合来自PAR-21-253授权者和更广泛的微生物的微生物代谢物发现和活性 代谢组学社区。CMMC将建立一个集中的微生物代谢物生物活性知识库 旨在与受赠者和社区合作，定义代表生物活动的标准，处理 社区知识和支持原始数据的证言，将证言汇总为确凿证据 知识，将知识应用于新数据，将知识传播到先前未表征的分子中，以及 与其他社区知识库整合，这些知识库包含微生物代谢物的补充知识。 所有数据、知识和工具都将变得可查找、可访问、可互操作和可重复使用(公平)。 该提案将1)建立微生物代谢物的网络门户，包括搜索、导出和分析 功能。2)与随附的R01授权者、NIDDK和 更大的科学界。3)协调数据共享活动、培训和技术支持，并组织 一年一度的会议。 绩效指标和共同信息系统非常适合满足需求和建立拟议的知识库，原因是 他们在微生物代谢组学(Dorrestein)、微生物组(Dorrestein，Knight)、知识库方面的专业知识 创作(Dorrestein，Wang，Knight，Bandeira)，社区推广(Dorrestein，Wang)，平台培训 (Dorrestein，Wang)、社区工具集成(Wang)、社区知识库集成(Dorrestein， Wang、Knight、Bandeira)、可扩展工具开发(Wang、Bandeira)和数据弹性(Wang、Bandeira)。

Project Summary/Abstract The interaction between our diet, metabolism by the microbiome, and the downstream biological effects on the host are key foundational knowledge that will guide the development of precision medicine integrated with nutrition. To characterize the function of these individual metabolites that are transformed from foods or fully synthesized by the microbiome will improve the mechanistic understanding of Microbe-Diet-Host interactions. Despite this importance, the community lacks a knowledge management center that centralizes and aggregates bioactivity and function of these metabolites that hinders the ability of researchers to reuse knowledge in a high throughput fashion and build off the discoveries of others. The proposed “Collaborative Microbial Metabolite Center” or CMMC proposed here will fill this void in the scientific landscape, aiming to integrate microbial metabolite discovery and activity from PAR-21-253 grantees and the broader microbial metabolomics community. The CMMC will build a centralized microbial metabolites bioactivity knowledge base that aims to work with the grantees and community to define standards to represent bioactivity, handle community depositions of knowledge and supporting raw data, aggregate depositions into corroborated knowledge, apply knowledge to new data, propagate knowledge into previous uncharacterized molecules, and integrate with other community knowledgebases that host complementary knowledge for microbial metabolites. All data, knowledge, and tools will be made findable, accessible, interoperable, and reusable (FAIR). This proposal will 1) Build the web portal for microbial metabolites with search, export, and analysis functions. 2) Build a microbial metabolite knowledgebase with the accompanying R01 grantees, NIDDK, and the larger scientific community. 3) Coordinate data sharing activities, training and technical support and organize a yearly meeting. The PIs and Co-Is are well suited to address the needs and build the proposed knowledge base, due to their expertise in microbial metabolomics (Dorrestein), microbiome (Dorrestein, Knight), knowledge base creation (Dorrestein, Wang, Knight, Bandeira), community outreach (Dorrestein, Wang), platform training (Dorrestein, Wang), community tool integration (Wang), community knowledgebase integration (Dorrestein, Wang, Knight, Bandeira), scalable tool development (Wang, Bandeira), and data resiliency (Wang, Bandeira).