Oklahoma Center for Microbial Pathogenesis and Immunity

俄克拉荷马州微生物发病机制和免疫中心

• 批准号: 10341201
• 负责人: Jimmy D. Ballard
• 金额: $ 216.67万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10341201
• 关键词: Address; Area; Bacterial Infections; Bacterial Toxins; Biology; Biomedical Research; Cellular Immunity; Centers of Research Excellence; Cessation of life; Collaborations; Communicable Diseases; Communities; Data; Discipline; Disease; Educational workshop; Elements; Ensure; Environment; Event; Eye Infections; Faculty; Fostering; Foundations; Funding; Future; Genetic; Goals; Gram-Positive Bacteria; Grant; Health; Health Sciences; Hospitals; Human; Immune response; Immune system; Immunity; Immunology; Infection; Inflammation; Infrastructure; Institution; Laboratory Research; Life; Mentors; Microbe; Microbial Biofilms; Microbiology; Mission; Modernization; Molecular; Necrotizing Enterocolitis; Oklahoma; Pathogenesis; Phase; Pilot Projects; Productivity; Program Sustainability; Regulation; Research; Research Infrastructure; Research Personnel; Research Priority; Research Project Grants; Resources; Science; Scientist; Strategic Planning; Structure; Technology; Therapeutic; Training; Translating; United States National Institutes of Health; Universities; Work; Writing; adaptive immunity; career; career development; cohort; collaborative environment; gut colonization; improved; innovation; microbial; microbiome; multidisciplinary; news; outreach; pathogen; pathogenic fungus; programs; recruit; success; sustainable resource; symposium; transcriptome

Abstract The goal of this Phase-1 COBRE program is to develop and enhance the research infrastructure, mentoring, and collaborative environment to support five Junior Investigators in the multi-disciplinary fields of microbial pathogenesis and immunity. To achieve this goal, The Oklahoma Center for Microbial Pathogenesis and Immunity (OCMP&I) COBRE will be established and fostered as a center of excellence focused on advancing the careers of Junior Investigators studying life-threatening infectious microbes and the ways in which the immune system responds to infection. The OCMP&I COBRE will be centrally located at the University of Oklahoma Health Sciences Center, the flagship academic institution for biomedical research in Oklahoma. The OCMP&I COBRE will initially include 17 scientists engaged in microbial pathogenesis and immunity research at research-intensive institutions in Oklahoma and this network will be expanded during the Phase-1 period as the center takes form and grows. Among these 17 scientists are five outstanding and promising Junior Investigators who study fungal pathogenesis, inflammation, regulation of biofilms, and necrotizing enterocolitis. The OCMP&I and its consortium of successful senior researcher scientists will provide the intellectual input and expertise to mentor each Junior Investigator to research independence. In addition to outstanding mentoring, The OCMP&I COBRE will provide the funding and research core support needed for Junior Investigators to succeed and become long-term contributors to the microbial pathogenesis and immunity research community in Oklahoma. Intertwined with the Junior Investigator support, will be the OCMP&I COBRE's mission to address gaps in infrastructure and resources that have limited the opportunities for cutting-edge research in our state. To achieve these objectives, the OCMP&I COBRE will be guided by four overall specific aims. Specific Aim 1: Establish a thematic center to enhance research, mentoring, and infrastructure support for microbial pathogenesis and immunity research in Oklahoma, Specific Aim 2: Select and support outstanding Junior Investigators, Specific Aim 3: Expand and enhance infrastructure to support innovative and collaborative research in microbial pathogenesis and immunity in Oklahoma. Specific Aim 4: Foster a culture of collaboration and team-science by providing opportunities for frequent scholarly interactions and outreach through seminars, symposiums, workshops, and pilot projects. Key elements for the success of the center include 1) the establishment of a single, but highly facile research core, that can immediately support the first group of Junior Investigator projects and expand to meet ever- changing research needs of investigators in microbial pathogenesis and immunity, 2) up date and modernize research laboratory space where Junior Investigators can work with established investigators and benefit from daily interactions, 3) Develop a pipeline of future Junior Investigators through targeted hires and through collaboration with a network of departmental leaders on multiple campuses, 4) Utilize and capitalize on current IDeA program resources in Oklahoma, and 5) Utilize an ongoing seminar program, sponsor a new annual symposium, and support a grant-writing workshop to encourage collaborative interactions and exchange of ideas among investigators in this multi-disciplinary area of research. Collectively, this five-year Phase-1 COBRE program will establish the first center of research excellence in Oklahoma focused on microbial pathogenesis and immunity and become the central entity that accelerates research by all investigators in these fields and provides a highly-supportive path to independence for our most promising Junior Investigators.

抽象的 该阶段1毛线计划的目标是开发和增强研究 基础设施，指导和协作环境，以支持五名初级调查人员 微生物发病机理和免疫力的多学科领域。为了实现这一目标， 俄克拉荷马州微生物发病机理和免疫（OCMP＆i）cobre中心将是 建立并建立为卓越中心，专注于促进初级职业 研究威胁生命的传染性微生物和免疫方式的研究者 系统应对感染。 OCMP＆i Cobre将位于大学 俄克拉荷马州卫生科学中心，旗舰学术研究机构 俄克拉荷马州。 OCMP＆i Cobre最初将包括17位从事微生物的科学家 俄克拉荷马州研究密集型机构的发病机理和免疫研究，这 随着中心的形式和增长，将在1阶段期间扩展网络。 在这17位科学家中，有五位杰出而有前途的初级调查员 真菌发病机理，炎症，生物膜调节和坏死性小肠结肠炎。这 OCMP＆I及其成功的高级研究员科学家的财团将提供 智力投入和专业知识，以指导每个初级研究者研究独立性。在 除了出色的指导外，OCMP＆i Cobre将提供资金和研究 初级调查人员成功并成为长期贡献者所需的核心支持 俄克拉荷马州的微生物发病机理和免疫研究界。交织在一起 初级调查员的支持将是OCMP＆i Cobre的使命，以解决差距 基础设施和资源限制了我们的尖端研究机会 状态。为了实现这些目标，OCMP＆i COBRE将由四个总体特定的指导 目标。特定目标1：建立一个主题中心，以增强研究，指导和 基础设施支持俄克拉荷马州微生物发病机理和免疫研究，特定 目标2：选择并支持杰出的初级调查人员，特定目标3：扩展和 增强基础设施以支持微生物的创新和协作研究 俄克拉荷马州的发病机理和免疫力。特定目的4：培养协作文化和 团队科学通过提供频繁进行学术互动的机会并通过 研讨会，研讨会，研讨会和试点项目。成功的关键要素 中心包括1）建立单个但高度便利的研究核心，可以 立即支持第一组初级调查员项目，并扩展以满足 - 改变研究者在微生物发病机理和免疫力中的研究需求，2）提升日期 并将研究人员可以与已建立的研究人员合作现代化实验室空间 研究人员并受益于每日互动，3）开发未来初级的管道 通过有针对性的员工以及与部门网络的合作调查人员 多个校园的领导者，4）利用并利用当前的思想计划资源 俄克拉荷马州和5）使用正在进行的研讨会计划，赞助新的年度研讨会，并 支持赠款写作研讨会，以鼓励协作互动和思想交流 在这个多学科研究领域的研究人员中。总的来说，这五年 第1阶段柯布尔计划将在俄克拉荷马州建立卓越研究中心 专注于微生物的发病机理和免疫力，并成为加速加速的中心实体 这些领域的所有研究人员的研究，为通往 我们最有前途的初级调查员的独立性。