Oklahoma Center for Microbial Pathogenesis and Immunity

俄克拉荷马州微生物发病机制和免疫中心

• 批准号: 10341201
• 负责人: Jimmy D. Ballard
• 金额: $ 216.67万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10341201
• 关键词: Address; Area; Bacterial Infections; Bacterial Toxins; Biology; Biomedical Research; Cellular Immunity; Centers of Research Excellence; Cessation of life; Collaborations; Communicable Diseases; Communities; Data; Discipline; Disease; Educational workshop; Elements; Ensure; Environment; Event; Eye Infections; Faculty; Fostering; Foundations; Funding; Future; Genetic; Goals; Gram-Positive Bacteria; Grant; Health; Health Sciences; Hospitals; Human; Immune response; Immune system; Immunity; Immunology; Infection; Inflammation; Infrastructure; Institution; Laboratory Research; Life; Mentors; Microbe; Microbial Biofilms; Microbiology; Mission; Modernization; Molecular; Necrotizing Enterocolitis; Oklahoma; Pathogenesis; Phase; Pilot Projects; Productivity; Program Sustainability; Regulation; Research; Research Infrastructure; Research Personnel; Research Priority; Research Project Grants; Resources; Science; Scientist; Strategic Planning; Structure; Technology; Therapeutic; Training; Translating; United States National Institutes of Health; Universities; Work; Writing; adaptive immunity; career; career development; cohort; collaborative environment; gut colonization; improved; innovation; microbial; microbiome; multidisciplinary; news; outreach; pathogen; pathogenic fungus; programs; recruit; success; sustainable resource; symposium; transcriptome

Abstract The goal of this Phase-1 COBRE program is to develop and enhance the research infrastructure, mentoring, and collaborative environment to support five Junior Investigators in the multi-disciplinary fields of microbial pathogenesis and immunity. To achieve this goal, The Oklahoma Center for Microbial Pathogenesis and Immunity (OCMP&I) COBRE will be established and fostered as a center of excellence focused on advancing the careers of Junior Investigators studying life-threatening infectious microbes and the ways in which the immune system responds to infection. The OCMP&I COBRE will be centrally located at the University of Oklahoma Health Sciences Center, the flagship academic institution for biomedical research in Oklahoma. The OCMP&I COBRE will initially include 17 scientists engaged in microbial pathogenesis and immunity research at research-intensive institutions in Oklahoma and this network will be expanded during the Phase-1 period as the center takes form and grows. Among these 17 scientists are five outstanding and promising Junior Investigators who study fungal pathogenesis, inflammation, regulation of biofilms, and necrotizing enterocolitis. The OCMP&I and its consortium of successful senior researcher scientists will provide the intellectual input and expertise to mentor each Junior Investigator to research independence. In addition to outstanding mentoring, The OCMP&I COBRE will provide the funding and research core support needed for Junior Investigators to succeed and become long-term contributors to the microbial pathogenesis and immunity research community in Oklahoma. Intertwined with the Junior Investigator support, will be the OCMP&I COBRE's mission to address gaps in infrastructure and resources that have limited the opportunities for cutting-edge research in our state. To achieve these objectives, the OCMP&I COBRE will be guided by four overall specific aims. Specific Aim 1: Establish a thematic center to enhance research, mentoring, and infrastructure support for microbial pathogenesis and immunity research in Oklahoma, Specific Aim 2: Select and support outstanding Junior Investigators, Specific Aim 3: Expand and enhance infrastructure to support innovative and collaborative research in microbial pathogenesis and immunity in Oklahoma. Specific Aim 4: Foster a culture of collaboration and team-science by providing opportunities for frequent scholarly interactions and outreach through seminars, symposiums, workshops, and pilot projects. Key elements for the success of the center include 1) the establishment of a single, but highly facile research core, that can immediately support the first group of Junior Investigator projects and expand to meet ever- changing research needs of investigators in microbial pathogenesis and immunity, 2) up date and modernize research laboratory space where Junior Investigators can work with established investigators and benefit from daily interactions, 3) Develop a pipeline of future Junior Investigators through targeted hires and through collaboration with a network of departmental leaders on multiple campuses, 4) Utilize and capitalize on current IDeA program resources in Oklahoma, and 5) Utilize an ongoing seminar program, sponsor a new annual symposium, and support a grant-writing workshop to encourage collaborative interactions and exchange of ideas among investigators in this multi-disciplinary area of research. Collectively, this five-year Phase-1 COBRE program will establish the first center of research excellence in Oklahoma focused on microbial pathogenesis and immunity and become the central entity that accelerates research by all investigators in these fields and provides a highly-supportive path to independence for our most promising Junior Investigators.

摘要 COBRE项目第一阶段的目标是发展和加强研究 基础设施，指导和协作环境，以支持五名初级研究员， 微生物致病和免疫的多学科领域。为了实现这一目标， 俄克拉荷马州微生物致病和免疫中心（OCMP&I）COBRE将在 建立和培养卓越的中心，专注于推进少年的职业生涯 研究威胁生命的传染性微生物以及免疫系统 系统对感染作出反应。OCMP&I COBRE将位于大学的中心位置， 俄克拉荷马州健康科学中心，生物医学研究的旗舰学术机构， 俄克拉荷马州。OCMP&I COBRE最初将包括17名从事微生物研究的科学家。 发病机制和免疫研究在研究密集型机构在俄克拉荷马州和这一点 随着中心的形成和发展，网络将在第一阶段扩大。 在这17名科学家中，有5名杰出而有前途的初级研究员，他们研究 真菌发病机制、炎症、生物膜调节和坏死性小肠结肠炎。的 OCMP&I及其成功的高级研究科学家联盟将提供 智力投入和专业知识，指导每个初级研究员独立研究。在 除了出色的指导外，OCMP&I COBRE还将提供资金和研究 初级研究者取得成功并成为长期贡献者所需的核心支持， 俄克拉荷马州的微生物致病和免疫研究团体。交织着 初级调查员支持，将是OCMP&I COBRE的使命，以解决 基础设施和资源，限制了我们的尖端研究的机会， 状态为了实现这些目标，OCMP&I COBRE将以四个总体具体目标为指导， 目标。具体目标1：建立一个专题中心，以加强研究、指导和 俄克拉荷马州微生物致病和免疫研究基础设施支持，具体 目标2：选择和支持优秀的初级研究员，具体目标3：扩大和 加强基础设施，支持微生物领域的创新和合作研究 发病机制和免疫俄克拉荷马州。具体目标4：培养合作文化， 通过提供频繁的学术互动和推广机会， 研讨会、专题讨论会、讲习班和试点项目。成功的关键因素 中心包括1）建立一个单一的，但非常容易的研究核心，可以 立即支持第一批初级研究员项目，并扩大到满足以往任何时候- 微生物发病机理和免疫研究者不断变化的研究需求，2）更新 现代化的研究实验室空间，初级研究人员可以与现有的 调查员和受益于日常互动，3）发展未来的初级管道 调查人员通过有针对性的雇用和通过与部门网络的合作， 多个校区的领导者，4）利用和利用当前的IDEA计划资源， 俄克拉荷马州，以及5）利用正在进行的研讨会计划，赞助新的年度研讨会，以及 支持赠款撰写讲习班，以鼓励协作互动和交流想法 在这个多学科研究领域的研究者中。总的来说，这五年 第一阶段COBRE计划将在俄克拉荷马州建立第一个卓越研究中心 专注于微生物发病机制和免疫，并成为加速 所有研究人员在这些领域的研究，并提供了一个高度支持的路径， 我们最有前途的初级调查员的独立性