Purchase of a Single Crystal X-Ray Diffractometer and Computer System

X射线结晶学技术是测定小分子多肽和复杂金属簇合物分子结构的有力工具。当与最新的计算机硬件和软件相结合时，这项技术变得非常容易实施。X射线晶体仪器的获得极大地提高了化学家开展前沿研究的能力。华盛顿大学化学系将利用化学共享仪器计划的这一奖项，帮助获得单晶X射线衍射仪和相关的计算机系统。收购将加强的化学研究领域包括：1)戊二烯-金属-膦配合物的合成和反应活性2)通往富磷簇合物和无机材料的分子路线；3)三重态卡宾类似物，多金属分子，4)杯芳烃作为酶模拟了生物有机化学和生物无机化学中的构效关系6)金属络合物作为诊断显像剂。

The technique of X-ray crystallography is a powerful tool for the determination of the molecular structure of compounds as diverse as small polypeptides and complex metal clusters. When combined with the latest computer hardware and software, the technique is becoming remarkably easy to put into practice. The acquisition of X-ray crystallographic instrumentation markedly improves the ability of chemists to cary out frontier research. The Department of Chemistry at Washington University will use this award from the Chemistry Shared Instrumentation Program to help acquire a single crystal X-ray diffractometer and an associated computer system. The areas of chemical research that will be enhanced by the acquisition include: 1) Synthesis and reactivity of pentadienyl-metal-phosphine complexes 2) Molecular routes to phosphorous-rich clusters and inorganic materials 3) Analogs of triplet carbenes, polyadamantalized molecules, and metallasilacycles 4) Calixarenes as enzyme mimics 5) Structure-activity relationships in bioorganic and bio- inorganic chemistry 6) Metal chelates as diagnostic imaging agents.