Purchase of a Single Crystal Defractometer for Use with Small Crystals

购买用于小晶体的单晶折射仪

• 批准号: 8050267
• 负责人: DENNIS P CURRAN
• 金额: $ 41.81万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8050267
• 关键词: Aging; Biological; Biological Factors; Catalysis; Chemistry; Complement; Copper; Crystallography; Development; Funding; Libraries; Methodology; Methods; Minor; Oligosaccharides; Peptide Synthesis; Pharmaceutical Chemistry; Postdoctoral Fellow; Radiation; Request for Proposals; Research; Roentgen Rays; Sampling; Services; Source; Structure; Students; Time; Tube; United States National Institutes of Health; X ray diffraction analysis; X-Ray Diffraction; drug discovery; drug synthesis; experience; instrument; instrumentation; seal; sensor; small molecule

DESCRIPTION (provided by applicant): This is a research instrumentation proposal that requests funding for a Bruker X8 Prospector Ultra Single Crystal X-ray Diffractometer. The diffractometer will be integrated into the existing Chemistry Department Core X-ray Diffraction Facility, which is in turn is part of a larger Small Molecule Characterization Core. The instrument will be shared by a group of seven major users with NIH funding (Curran (PI), Brummond, Floreancig, Koide, Nelson, Wilcox, Wipf) and three minor users. It will be used primarily to solve the crystal structures of small and medium-sized organic molecules and biomolecules. The instrument will be operated by a full time Director of Crystallography with over two decades of experience, and will provide services to about 80 students and postdoctoral fellows on NIH-supported projects. The new diffractometer with a modern copper X-ray source will complement an aging but still useful diffractometer with conventional sealed tube Mo K? radiation. The new diffractometer will expedite the research of these groups by providing structures from smaller crystals (a critical current need), by providing rapid turn around time on synthetic intermediates, and by solving absolute configurations of samples without heavy atoms. This is a crucial support instrument for research in medicinal chemistry, diversity-oriented synthesis, library synthesis, synthetic methodology, catalysis development, sensor synthesis, natural products synthesis, and synthesis of peptides and oligosaccharides. Biomedical themes are replete and include drug discovery, biological probe discovery, new methods for drug synthesis, analysis of biological milieu, and understanding and imitation of important biomolecules. PUBLIC HEALTH RELEVANCE: This is a research instrumentation proposal that requests funding for a Bruker X8 Prospector Ultra Single Crystal X-ray Diffractometer. The instrument will be shared by a group of seven major users (all NIH funded) and three minor users primarily to solve the crystal structures of small and medium-sized organic molecules. This is a crucial support instrument for research in medicinal chemistry, diversity-oriented synthesis, library synthesis, synthetic methodology, sensor synthesis, natural products synthesis, and synthesis of peptides and oligosaccharides. Biomedical themes are replete and include drug discovery, biological probe discovery, new methods for drug synthesis, analysis of biological milieu, and understanding and imitation of important biomolecules.

描述（由申请人提供）：这是一份研究仪器提案，要求为布鲁克X8 Prospector超单晶X射线衍射仪提供资金。衍射仪将被集成到现有的化学系核心X射线衍射设施，这反过来又是一个更大的小分子表征核心的一部分。该仪器将由NIH资助的七个主要用户（Curran（PI），Brummond，Floreancig，Koide，纳尔逊，Wilcox，Wipf）和三个次要用户共享。它将主要用于解决小型和中型有机分子和生物分子的晶体结构。该仪器将由一位拥有二十多年经验的全职晶体学主任操作，并将为大约80名NIH支持项目的学生和博士后研究员提供服务。新的衍射仪与现代铜X射线源将补充老化，但仍然有用的衍射仪与传统的密封管钼K？辐射新的衍射仪将通过提供更小晶体的结构（当前的关键需求），通过提供合成中间体的快速周转时间，以及通过解决没有重原子的样品的绝对构型来加快这些群体的研究。这是药物化学、多样性导向合成、库合成、合成方法学、催化开发、传感器合成、天然产物合成以及肽和寡糖合成研究的重要支持工具。生物医学的主题很丰富，包括药物发现，生物探针发现，药物合成的新方法，生物环境的分析，以及重要生物分子的理解和模仿。 公共卫生相关性：这是一份研究仪器提案，要求为布鲁克X8 Prospector超单晶X射线衍射仪提供资金。该仪器将由七个主要用户（均由NIH资助）和三个次要用户共享，主要用于解决中小型有机分子的晶体结构。这是药物化学、多样性导向合成、库合成、合成方法学、传感器合成、天然产物合成以及肽和寡糖合成研究的重要支持工具。 生物医学的主题很丰富，包括药物发现，生物探针发现，药物合成的新方法，生物环境的分析，以及重要生物分子的理解和模仿。