Purchase of a Single Crystal Defractometer for Use with Small Crystals

描述(由申请人提供)：这是一份研究仪器提案，要求为Bruker X8 Prospector超单晶X射线衍射仪提供资金。衍射仪将被集成到现有的化学系核心X射线衍射设备中，而该设备又是更大的小分子表征核心的一部分。该仪器将由NIH资助的七个主要用户(Curran(PI)、Brummond、Floreancig、Koide、Nelson、Wilcox、Wipf)和三个小用户共享。它将主要用于解决中小型有机分子和生物分子的晶体结构。该仪器将由一名拥有20多年经验的全职结晶学主任操作，并将为NIH支持的项目中约80名学生和博士后研究员提供服务。采用现代铜X射线源的新衍射仪将补充老化但仍然有用的传统密封管MoK？辐射。新的衍射仪将通过提供更小晶体的结构(关键的电流需求)、通过提供合成中间体的快速周转时间以及通过解决没有重原子的样品的绝对构型来加速这些基团的研究。这是药物化学、多样性合成、文库合成、合成方法学、催化开发、传感器合成、天然产物合成以及多肽和寡糖合成等研究的重要支撑工具。生物医学的主题很丰富，包括药物发现、生物探针发现、药物合成新方法、生物环境分析以及对重要生物分子的理解和模拟。 与公共健康相关：这是一项研究仪器提案，要求为Bruker X8 Prospector超单晶X射线衍射仪提供资金。该仪器将由七个主要用户(全部由NIH资助)和三个次要用户共享，主要用于解决中小型有机分子的晶体结构。这是药物化学、多样性合成、文库合成、合成方法学、传感器合成、天然产物合成以及多肽和寡糖合成等研究的重要支撑工具。 生物医学的主题很丰富，包括药物发现、生物探针发现、药物合成新方法、生物环境分析以及对重要生物分子的理解和模拟。

DESCRIPTION (provided by applicant): This is a research instrumentation proposal that requests funding for a Bruker X8 Prospector Ultra Single Crystal X-ray Diffractometer. The diffractometer will be integrated into the existing Chemistry Department Core X-ray Diffraction Facility, which is in turn is part of a larger Small Molecule Characterization Core. The instrument will be shared by a group of seven major users with NIH funding (Curran (PI), Brummond, Floreancig, Koide, Nelson, Wilcox, Wipf) and three minor users. It will be used primarily to solve the crystal structures of small and medium-sized organic molecules and biomolecules. The instrument will be operated by a full time Director of Crystallography with over two decades of experience, and will provide services to about 80 students and postdoctoral fellows on NIH-supported projects. The new diffractometer with a modern copper X-ray source will complement an aging but still useful diffractometer with conventional sealed tube Mo K? radiation. The new diffractometer will expedite the research of these groups by providing structures from smaller crystals (a critical current need), by providing rapid turn around time on synthetic intermediates, and by solving absolute configurations of samples without heavy atoms. This is a crucial support instrument for research in medicinal chemistry, diversity-oriented synthesis, library synthesis, synthetic methodology, catalysis development, sensor synthesis, natural products synthesis, and synthesis of peptides and oligosaccharides. Biomedical themes are replete and include drug discovery, biological probe discovery, new methods for drug synthesis, analysis of biological milieu, and understanding and imitation of important biomolecules. PUBLIC HEALTH RELEVANCE: This is a research instrumentation proposal that requests funding for a Bruker X8 Prospector Ultra Single Crystal X-ray Diffractometer. The instrument will be shared by a group of seven major users (all NIH funded) and three minor users primarily to solve the crystal structures of small and medium-sized organic molecules. This is a crucial support instrument for research in medicinal chemistry, diversity-oriented synthesis, library synthesis, synthetic methodology, sensor synthesis, natural products synthesis, and synthesis of peptides and oligosaccharides. Biomedical themes are replete and include drug discovery, biological probe discovery, new methods for drug synthesis, analysis of biological milieu, and understanding and imitation of important biomolecules.