Chemical Signal Detection: Filter Properties of Chemoreceptor Organs

化学信号检测：化学感受器器官的过滤特性

• 批准号: 8812952
• 负责人: Jelle Atema
• 金额: $ 45.16万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-15 至 1993-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8812952&HistoricalAwards=false
• 关键词: Chemical; Signal; Detection; Filter; Properties

This is a project to study some of the physical factors involved in sensing of chemicals. The basic issue being approached is how the chemicals that are being sensed are transported to the receptor organs, and how the processes are modified by evolutionary specializations in morphology and behavior. The animal model of chemical sensing that is used is the detection of amino acids by lobster olfactory receptors. In these animals the amino acids, which are feeding stimuli, diffuse to the receptors. In doing so, they finally must diffuse through very thin layers of fluid adjacent to the organs themselves. Different chemoreceptor organs, even in the same animal, can have dramatically different morphology that can result in different diffusion layers. In addition, the animal's behaviors in sampling the environment (flicking and sniffing, for example), affect the boundary layer and also help to minimize the confounding effects of turbulence in the environment. The project will include testing a computational model of receptor organ filtering by measuring and manipulating diffusion layers in different chemoreceptor organs and measuring the time courses of responses in the cells in the living animals. Thus, it will result in an understanding of the structure and function of diffusion layers and of their contribution to analysis of chemical signals. The principles of filtering being studied here in the lobster are important components of all chemical sensing systems. They are little studied and poorly understood, and the conclusions drawn in this study should have wide generalizability to other systems as we..

这是一个研究一些物理因素的项目 在化学物质的感应中。 正在处理的基本问题是如何 被检测到的化学物质被输送到 受体器官，以及这些过程如何被 形态和行为的进化特化。 所使用的化学传感的动物模型是 用龙虾嗅觉受体检测氨基酸。 在 这些动物的氨基酸，这是喂养刺激，扩散 到受体。 在这样做的过程中，它们最终必须通过 器官附近有很薄的液体层 不同的化学感受器器官，即使在同一种动物中， 形态上的巨大差异， 扩散层 此外，动物的行为在 对环境进行采样（例如，轻弹和嗅探）， 影响边界层，也有助于减少 环境中湍流的混杂效应。 该项目将包括测试一个计算模型， 通过测量和操纵扩散的受体器官过滤 在不同的化学感受器器官和测量的时间层 活体动物细胞的反应过程。 因此，在本发明中， 这将有助于我们了解 扩散层及其对分析 化学信号 在龙虾中研究的过滤原理是 所有化学传感系统的重要组成部分。 他们是 很少研究和了解，得出的结论 在这项研究应该有广泛的推广到其他系统 当我们...