Filter Properties of Chemoreceptor Cells

9222774 Atema感官受体处理刺激随时间快速变化的方式在化学接收(嗅觉和味觉)中还没有太多的研究，重点一直是分子识别。然而，复杂而动态的气味是自然环境的特征，对于大脑如何将化学感觉信号整合到适当的行为中可能是非常重要的。这项工作开发了新的电化学测量技术，用于在非常容易访问的海洋甲壳类天线模型系统上研究嗅觉感受器的空间和时间分辨率。一种新的严格控制的刺激传递技术允许使用各种刺激参数，同时测量反应参数的大小和可靠性，观察激励和适应模式等影响。这些数据将被纳入化学感觉动力学模型，并扩展到受体发育和中央编码的研究中。这项工作将不仅对化学传感神经生物学产生影响，还将对食品工业和医药的嗅觉和味觉性能诊断测试领域产生影响，并对用于生态和渔业开发的水下化学传感机器人设备的潜在生物技术开发产生影响。***

9222774 Atema The way in which sensory receptors process rapid changes of stimulus over time has not been studied much in chemical reception (smell and taste), where the emphasis has been on molecular recognition. Yet complex and dynamic odors characterize the natural environment, and are likely to be very important to how the brain integrates chemosensory signals into appropriate behavior. This work develops novel electrochemical measuring techniques for investigating the spatial and temporal resolution of olfactory receptors on the very accessible model system of the antenna of marine crustaceans. A new tightly-controlled stimulus delivery technology allows a variety of stimulus parameters to be used while measuring the magnitude and reliability of response parameters, looking at effects such as excitation and adaptation patterns. The data will be incorporated into a model of chemosensory dynamics, and extended in studies on receptor development and central coding. This work will have impact beyond chemosensory neurobiology into areas of diagnostic tests for smell and taste performance for the food industry as well as medicine, and to the potential biotechnological development of underwater chemosensing robotic devices for ecology and for fisheries exploitation. ***