Filter Properties of Chemoreceptor Cells

化学感受器细胞的过滤特性

• 批准号: 9222774
• 负责人: Jelle Atema
• 金额: $ 33.08万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-15 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9222774&HistoricalAwards=false
• 关键词: Filter; Properties; Chemoreceptor; Cells

9222774 Atema The way in which sensory receptors process rapid changes of stimulus over time has not been studied much in chemical reception (smell and taste), where the emphasis has been on molecular recognition. Yet complex and dynamic odors characterize the natural environment, and are likely to be very important to how the brain integrates chemosensory signals into appropriate behavior. This work develops novel electrochemical measuring techniques for investigating the spatial and temporal resolution of olfactory receptors on the very accessible model system of the antenna of marine crustaceans. A new tightly-controlled stimulus delivery technology allows a variety of stimulus parameters to be used while measuring the magnitude and reliability of response parameters, looking at effects such as excitation and adaptation patterns. The data will be incorporated into a model of chemosensory dynamics, and extended in studies on receptor development and central coding. This work will have impact beyond chemosensory neurobiology into areas of diagnostic tests for smell and taste performance for the food industry as well as medicine, and to the potential biotechnological development of underwater chemosensing robotic devices for ecology and for fisheries exploitation. ***

9222774 Atema在化学接受（嗅觉和味觉）中，感觉受体处理刺激随时间快速变化的方式尚未得到太多研究，其重点一直放在分子识别上。然而，复杂和动态的气味是自然环境的特征，并且可能对大脑如何将化学感觉信号整合到适当的行为中非常重要。本研究开发了一种新的电化学测量技术，用于研究海洋甲壳类动物天线模型系统中嗅觉受体的时空分辨率。一种新的严格控制的刺激传递技术允许使用各种刺激参数，同时测量响应参数的大小和可靠性，观察诸如激励和适应模式等效应。这些数据将被纳入化学感觉动力学模型，并扩展到受体发育和中枢编码的研究中。这项工作的影响将超越化学感觉神经生物学，进入食品工业和医学嗅觉和味觉性能诊断测试领域，并对生态和渔业开发水下化学传感机器人设备的潜在生物技术发展产生影响。＊＊＊