Filter Properties of Chemoreceptor Cells

小行星9222774 感觉受体处理刺激随时间快速变化的方式在化学感受（嗅觉和味觉）中研究得不多，其中重点是分子识别。 然而，复杂和动态的气味是自然环境的特征，并且可能对大脑如何将化学感觉信号整合到适当的行为中非常重要。 这项工作开发了新的电化学测量技术，用于研究海洋甲壳类动物触角的非常容易的模型系统上的嗅觉受体的空间和时间分辨率。 一种新的严格控制的刺激传递技术允许使用各种刺激参数，同时测量响应参数的幅度和可靠性，查看诸如激励和适应模式等效果。 这些数据将被纳入化学感受动力学模型，并扩展到受体发育和中枢编码的研究中。 这项工作将影响到化学感觉神经生物学以外的领域，为食品工业和医学的嗅觉和味觉性能的诊断测试，以及潜在的生物技术开发水下化学传感机器人设备的生态和渔业开发。 ***

9222774 Atema The way in which sensory receptors process rapid changes of stimulus over time has not been studied much in chemical reception (smell and taste), where the emphasis has been on molecular recognition. Yet complex and dynamic odors characterize the natural environment, and are likely to be very important to how the brain integrates chemosensory signals into appropriate behavior. This work develops novel electrochemical measuring techniques for investigating the spatial and temporal resolution of olfactory receptors on the very accessible model system of the antenna of marine crustaceans. A new tightly-controlled stimulus delivery technology allows a variety of stimulus parameters to be used while measuring the magnitude and reliability of response parameters, looking at effects such as excitation and adaptation patterns. The data will be incorporated into a model of chemosensory dynamics, and extended in studies on receptor development and central coding. This work will have impact beyond chemosensory neurobiology into areas of diagnostic tests for smell and taste performance for the food industry as well as medicine, and to the potential biotechnological development of underwater chemosensing robotic devices for ecology and for fisheries exploitation. ***