US-France Cooperative Research: Genetic Aspects of Insect Immunity and Parasite Resistance

美法合作研究：昆虫免疫和寄生虫抗性的遗传方面

• 批准号: 8815410
• 负责人: Anthony Nappi
• 金额: $ 0.33万
• 依托单位: Loyola University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8815410&HistoricalAwards=false
• 关键词: US; France; Cooperative; Research; Genetic

This award will support collaborative research between Dr. Anthony J. Nappi, Loyola University of Chicago and Dr. Yves Carton, Laboratoire de Biologie et Genetique Evolutives, Gif-sur-Yvette, France. The objective of this project is to elucidate the genetic basis of immune recognition/regulation and parasite resistance in insects. The investigators will study: 1) the role of cellular and humoral catecholamine metabolizing enzymes during melanotic encapsulation responses in genetically well-defined enzyme mutants, (2) the immune response of different geographical species and strains of filed collected hosts, and (3) the mechanisms of resistance by different geographic species and strains of parasites. In order to ascertain the biosynthetic pathways employed in the production of the cross-linking agents that form melanotic capsules, cytological and biochemical studies will be performed of the immune responses generated in larvae of Drosophila __________ melanogaster, a host for the wasp parasitoids Leptopilina ____________ ___________ heterotoma and L. boulardi. __________ _ ________ This project will combine Dr. Nappi's expertise in enzyme assays with the availability in the French laboratory of specific genetic lines of fly and wasp for the dissection of resistance mechanisms. The results of this research will contribute to the understanding of: 1) coevolutionary relationships between parasite and host, and 2) efficiency of use of parasites in the biological control of insect pests.

该奖项将支持安东尼博士之间的合作研究 芝加哥洛约拉大学的J. Nappi和Yves Carton博士， 生物学和进化遗传学研究所，伊维特河畔吉夫， 法国 这个项目的目的是阐明基因 免疫识别/调节和寄生虫抗性的基础 昆虫 研究人员将研究：1）细胞的作用， 黑色素变性过程中的体液儿茶酚胺代谢酶 在遗传上明确定义的酶突变体中的包封反应， (2)不同地理物种的免疫反应， 菌株的田间收集的主机，（3）的机制， 不同地理物种和菌株的抗性 寄生虫 为了确定生物合成途径 用于生产交联剂， 黑色素囊，细胞学和生化研究将 果蝇幼虫产生的免疫反应 __________ 黑腹蜂属Leptopilina ____________ ___________ heterotoma和L.布拉迪。 __________ _ ________ 该项目将结合联合收割机博士Nappi的专业知识，在酶测定 在法国实验室里， 苍蝇和黄蜂的线条，用于解剖抗性机制。 这项研究的结果将有助于理解 （1）寄生虫和宿主之间的共同进化关系， 2)在生物防治中利用寄生虫的效率 害虫