U.S. - U.K. Cooperative Research: Studies of Reactive Oxygen Species in Insect Immunity

美英合作研究：活性氧在昆虫免疫中的研究

• 批准号: 9872603
• 负责人: Anthony Nappi
• 金额: $ 0.4万
• 依托单位: Loyola University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9872603&HistoricalAwards=false
• 关键词: U.S.; U.K.; Cooperative; Research; Studies

9872603NappiThis three-year award supports US-UK collaborative research on insect immunity and resistance to parasites between Anthony Nappi of Loyola University and Norman Ratcliffe of the University of Wales. The objective of their research is to elucidate the nature of the cytotoxic components generated by insects that specifically target and destroy their endoparasites. The research will establish whether immune responses in insects involve the enhanced production of such cytotoxic reactive oxygen species (ROS) as superoxide, hydrogen peroxide, hydroxyl radical, and nitric oxide. The production of these ROS molecules will be monitored in insect host-parasite systems: Drosophila melanogaster and the parasite the cnynipid wasp, Leptopilina boulardi, and Rhodnius prolixus and its parasite, the protozoan Trypanosoma rangeli.The US investigator brings to this collaboration expertise in reactive oxygen molecules. This is complemented by the UK investigator's extensive experience with insect/host parasite systems. The identification of cytotoxic molecules and knowledge of how they are produced will provide fundamental knowledge about the immune recognition system in insects.

这个为期三年的奖项支持洛约拉大学的安东尼·纳皮（Anthony Nappi）和威尔士大学的诺曼·拉特克里夫（Norman Ratcliffe）在昆虫免疫和寄生虫抗性方面的美英合作研究。他们的研究目的是阐明昆虫产生的细胞毒性成分的性质，这些成分专门针对并摧毁它们的内寄生虫。这项研究将确定昆虫的免疫反应是否涉及细胞毒性活性氧（ROS）如超氧化物、过氧化氢、羟基自由基和一氧化氮的增加。这些活性氧分子的产生将在昆虫宿主-寄生虫系统中进行监测：黑腹果蝇和寄生蜂、波拉底瘦蝇、长尾红蝇和它的寄生虫、原生动物兰氏锥虫。这位美国研究者为这次合作带来了活性氧分子方面的专业知识。这与英国研究者在昆虫/宿主寄生虫系统方面的丰富经验相辅相成。细胞毒性分子的鉴定和它们如何产生的知识将提供有关昆虫免疫识别系统的基本知识。