A Chemical Investigation of Turkish Papaver Species

摘要叙述 描述：本项目支持博士的科学合作。 宾夕法尼亚州立大学化学系的莫里斯·沙玛 伊斯坦布尔大学药学院Gunay Sariyar博士 土耳其伊斯坦布尔大学。 这项研究是为了重新分离 土耳其罂粟植物物种的化学特征，以确定 在该物种中出现的生物碱部分。 此外该 研究人员将分析这些植物的中性和酸性提取物， 植物，因为很少的工作已经进行了这些 非基本成分。 在足够大的体积中获得的所有化合物 金额将转交给国家卫生研究所， 筛选抗肿瘤和抗HIV活性。 他们还将 经过农业用途的化学测试。 范围：本项目计划由土耳其P.I.识别和 _____ 在土耳其采集天然植物。 植物提取将完成 在伊斯坦布尔大学学习， 化合物的鉴定。 研究数据和样本然后 到宾夕法尼亚州立大学进行更高水平的纯化， 化学成分鉴定。 土耳其P.I.将 参与这项先进的研究和数据汇编。 的 促进国际科学知识交流， 培训和使用发展中国家的科学家， 发展中国家科学计划的主要目标。

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Gunay Sariyar of the Faculty of Pharmacy, Istanbul University, Istanbul Turkey. The research is to reisolate the chemical character of the Turkish Papaver plant species to determine the alkaloidal fractions that occur in the species. In addition, the investigators will analyze the neutral and acidic extracts of these plants because very little work has been carried out on these non-basic components. All compounds obtained in sufficiently large amounts will be forwarded to the National Institute of Health for screening for anti-tumor and anti-HIV activity. They will also be tested commericially for agricultural use. Scope: This project is planned to have the Turkish P.I. identify and _____ gather the natural plants in Turkey. Plant extraction will be done at Istanbul University followed by initial separation and identification of compounds. The research data and samples then go to Penn State University for higher level purification and identification of chemical components. The Turkish P.I. will participate in this advanced research and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.