A Chemical Investigation of Turkish Papaver Species

摘要叙述：该项目支持宾夕法尼亚州立大学化学系的Maurice Shamma博士和土耳其伊斯坦布尔大学药学院的Gunay Sariyar博士的科学合作。这项研究是为了重新分离土耳其罂粟属植物的化学性质，以确定该物种中出现的生物碱部分。此外，调查人员将分析这些植物的中性和酸性提取物，因为对这些非碱性成分的研究工作很少。所有大量获得的化合物都将被送往国家卫生研究所进行抗肿瘤和抗艾滋病毒活性的筛查。它们还将接受农业用途的商业测试。范围：该项目计划让土耳其私人投资者识别并_采集土耳其的自然植物。将在伊斯坦布尔大学进行植物提取，然后对化合物进行初步分离和鉴定。研究数据和样本随后被送往宾夕法尼亚州立大学进行更高级别的纯化和化学成分鉴定。土耳其私人情报局将参与这项高级研究和数据汇编。促进国际科学知识交流以及发展中国家科学家的培训和使用，实现了发展中国家科学方案的一项主要目标。

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Gunay Sariyar of the Faculty of Pharmacy, Istanbul University, Istanbul Turkey. The research is to reisolate the chemical character of the Turkish Papaver plant species to determine the alkaloidal fractions that occur in the species. In addition, the investigators will analyze the neutral and acidic extracts of these plants because very little work has been carried out on these non-basic components. All compounds obtained in sufficiently large amounts will be forwarded to the National Institute of Health for screening for anti-tumor and anti-HIV activity. They will also be tested commericially for agricultural use. Scope: This project is planned to have the Turkish P.I. identify and _____ gather the natural plants in Turkey. Plant extraction will be done at Istanbul University followed by initial separation and identification of compounds. The research data and samples then go to Penn State University for higher level purification and identification of chemical components. The Turkish P.I. will participate in this advanced research and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.