A Chemical Investigation of Turkish Papaver Species

土耳其罂粟品种的化学研究

• 批准号: 8815783
• 负责人: Maurice Shamma
• 金额: $ 2万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8815783&HistoricalAwards=false
• 关键词: Chemical; Investigation; Turkish; Papaver; Species

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Gunay Sariyar of the Faculty of Pharmacy, Istanbul University, Istanbul Turkey. The research is to reisolate the chemical character of the Turkish Papaver plant species to determine the alkaloidal fractions that occur in the species. In addition, the investigators will analyze the neutral and acidic extracts of these plants because very little work has been carried out on these non-basic components. All compounds obtained in sufficiently large amounts will be forwarded to the National Institute of Health for screening for anti-tumor and anti-HIV activity. They will also be tested commericially for agricultural use. Scope: This project is planned to have the Turkish P.I. identify and _____ gather the natural plants in Turkey. Plant extraction will be done at Istanbul University followed by initial separation and identification of compounds. The research data and samples then go to Penn State University for higher level purification and identification of chemical components. The Turkish P.I. will participate in this advanced research and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.

摘要叙述说明：该项目支持宾夕法尼亚州立大学化学系的Maurice Shamma博士和伊斯坦布尔大学伊斯坦布尔大学药学院的Gunay Sariyar博士。 这项研究是重新分离土耳其辣椒植物物种的化学特征，以确定该物种中发生的生物碱级分。 此外，研究人员将分析这些植物的中性和酸性提取物，因为这些非基本成分的工作很少。 所有以足够大量的化合物将转发给美国国家卫生研究院以筛查抗肿瘤和抗HIV活性。 他们还将在商业上进行农业用途的测试。 范围：该项目计划拥有土耳其P.I.识别并_____在土耳其收集天然植物。 植物提取将在伊斯坦布尔大学进行，然后进行初始分离和化合物的鉴定。 然后，研究数据和样本前往宾夕法尼亚州立大学进行更高级别的纯化和化学成分的识别。 土耳其P.I.将参与此高级研究和数据汇编。 国际科学知识交流以及发展中国家的培训和使用的进步实现了发展中国家科学计划的主要目标。