A Chemical Investigation of Turkish Papaver Species

摘要项目简介：本项目支持美国宾夕法尼亚州立大学化学系Maurice Shamma博士和土耳其伊斯坦布尔大学药学院Gunay Sariyar博士的科学合作。本研究是重新分离土耳其木瓜植物物种的化学特性，以确定该物种中出现的生物碱组分。此外，研究人员将分析这些植物的中性和酸性提取物，因为对这些非碱性成分的研究很少。所有获得的足够大的化合物将被转发给国家卫生研究所进行抗肿瘤和抗艾滋病毒活性的筛查。它们还将进行农业用途的商业测试。项目范围：本项目计划由土耳其私家侦探鉴定并_____采集土耳其的天然植物。植物提取将在伊斯坦布尔大学进行，然后进行化合物的初步分离和鉴定。研究数据和样品随后将送往宾夕法尼亚州立大学进行更高层次的净化和化学成分的鉴定。土耳其私家侦探将参与这项先进的研究和数据汇编。促进科学知识的国际交流，培养和利用发展中国家的科学家，是科学在发展中国家计划的一个主要目标。

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Gunay Sariyar of the Faculty of Pharmacy, Istanbul University, Istanbul Turkey. The research is to reisolate the chemical character of the Turkish Papaver plant species to determine the alkaloidal fractions that occur in the species. In addition, the investigators will analyze the neutral and acidic extracts of these plants because very little work has been carried out on these non-basic components. All compounds obtained in sufficiently large amounts will be forwarded to the National Institute of Health for screening for anti-tumor and anti-HIV activity. They will also be tested commericially for agricultural use. Scope: This project is planned to have the Turkish P.I. identify and _____ gather the natural plants in Turkey. Plant extraction will be done at Istanbul University followed by initial separation and identification of compounds. The research data and samples then go to Penn State University for higher level purification and identification of chemical components. The Turkish P.I. will participate in this advanced research and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.