A Chemical Investigation of Turkish Papaver Species

土耳其罂粟品种的化学研究

• 批准号: 8815783
• 负责人: Maurice Shamma
• 金额: $ 2万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8815783&HistoricalAwards=false
• 关键词: Chemical; Investigation; Turkish; Papaver; Species

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Gunay Sariyar of the Faculty of Pharmacy, Istanbul University, Istanbul Turkey. The research is to reisolate the chemical character of the Turkish Papaver plant species to determine the alkaloidal fractions that occur in the species. In addition, the investigators will analyze the neutral and acidic extracts of these plants because very little work has been carried out on these non-basic components. All compounds obtained in sufficiently large amounts will be forwarded to the National Institute of Health for screening for anti-tumor and anti-HIV activity. They will also be tested commericially for agricultural use. Scope: This project is planned to have the Turkish P.I. identify and _____ gather the natural plants in Turkey. Plant extraction will be done at Istanbul University followed by initial separation and identification of compounds. The research data and samples then go to Penn State University for higher level purification and identification of chemical components. The Turkish P.I. will participate in this advanced research and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.

摘要叙述 描述：该项目支持宾夕法尼亚州立大学化学系的 Maurice Shamm 博士和土耳其伊斯坦布尔伊斯坦布尔大学药学院的 Gunay Sariyar 博士的科学合作。 该研究旨在重新分离土耳其罂粟植物物种的化学特征，以确定该物种中存在的生物碱组分。 此外，研究人员还将分析这些植物的中性和酸性提取物，因为对这些非碱性成分进行的工作很少。 所有获得的足够大数量的化合物将被转发至国立卫生研究院进行抗肿瘤和抗艾滋病毒活性筛选。 它们还将针对农业用途进行商业测试。 范围：该项目计划让土耳其 P.I.识别并___收集土耳其的天然植物。 植物提取将在伊斯坦布尔大学进行，然后对化合物进行初步分离和鉴定。 研究数据和样品随后被送往宾夕法尼亚州立大学进行更高水平的纯化和化学成分鉴定。 土耳其 P.I.将参与这项高级研究和数据整理。 促进科学知识的国际交流以及发展中国家科学家的培训和使用实现了发展中国家科学计划的主要目标。