A Chemical Investigation of the Jordanian Flora

描述：本项目支持约旦大学的一位科学家（M.H. Abu Zarga博士）与宾夕法尼亚州立大学化学系的Maurice Shamma博士共同参与一项研究项目，研究约旦多种植物的化学成分。这些植物将包括巴勒斯坦Androcymbium，秋水仙和阿根廷Paronychia gentea。这位约旦科学家将在宾夕法尼亚州立大学花大约五个月的时间对这些植物的成分进行深入的化学分析。前两种植物富含生物碱。第三种是生物碱含量不高，但民间医学中使用，其化学成分包括萜类、黄酮类和木脂素，需要分离。在研究中获得的纯化合物将转交给美国国立卫生研究院进行临床研究，并向工业测试可能的农业应用。经营范围：PI是天然产物化学研究领域的世界级专家。他与约旦科学家合作的研究可能会使人们更好地了解所研究植物的化学成分，并使美国和约旦科学家更好地合作，从而可能发现药理学上有趣的化合物。

Description: This project supports participation by a scientist from the University of Jordan (Dr. M.H. Abu Zarga) in a research project with Dr. Maurice Shamma of the Chemistry Department, Pennsylvania State University to investigate the chemical contents of a variety of Jordanian plants. The plants will include Androcymbium palestinum, Colchicum decaisnei, and Paronychia argentea. The Jordanian scientist will spend about five months at Penn State for in-depth chemical analysis of these plants' contents. The first two plants are known to be rich in alkaloids. The third is not rich in alkaloids but is used in folk medicine and it is desirable to separate its chemical constituents including terpenoids, flavonoids and lignans. Pure compounds obtained in the research will be forwarded to NIH for their clinical research and to industry to test for possible agricultural applications. Scope: The PI is a world expert in the research on natural products' chemistry. His research in collaboration with the Jordanian scientist is likely to result in a better understanding of the chemistry of the plants being studied, and in better cooperation between scientists of the U.S. and Jordan which could lead to discovery of possible pharmacologically interesting compounds.