Alkaloids from Turkish Plants

摘要叙述：该项目支持宾夕法尼亚州立大学化学系的Maurice Shamma博士和土耳其伊兹密尔的爱琴海大学(University Of The Aegean)药学院的Tekant Gozler博士和Belkis Gozler博士(夫人)的科学合作。这项研究是正在进行的名为“土耳其植物中的生物碱”研究的继续。研究目标是从植物来源中分离和鉴定新的和不寻常的天然产物，特别是生物碱。如果获得足够大量的新化合物，将对其药理活性进行筛选。此外，分离出的新天然产物可能为了解植物中发生的生物遗传过程提供新的见解。将被调查的土耳其植物是秋水仙草和_这项研究的动力来自于最近的一份报告(纽约时报，1987年11月1日，第33页)，秋水仙素本身显著延长了肝炎患者的生命，甚至逆转了肝炎对肝脏的损害，其次，目前，美国对新秋水仙碱的研究很少。范围：该项目旨在让土耳其的_合作者识别和收集土耳其的自然植物。然后，他们提取、提纯、鉴定和测试所获得的化合物。研究数据和样本被送往美国首席调查员进行进一步分析。土耳其科学家与宾夕法尼亚州立大学的美国科学家一起参与了这项先进的测试和数据汇编。促进国际科学知识交流以及发展中国家科学家的培训和使用，实现了发展中国家科学方案的一项主要目标。

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Tekant Gozler and Dr. (Mrs) Belkis Gozler of the Faculty of Pharmacy, Ege University, (University of the Aegean), Izmir, Turkey. The research is to be a continuation of on going research entitled "Alkaloids for Turkish Plants". The research objectives are to isolate and characterize new and unusual natural products, particularly alkaloids, from plant sources. New compounds obtained will be screened for pharmacological activity, if obtained in sufficiently large quantities. Additionally, the novel natural products isolated may furnish new insights into the biogenetic processes occurring in plants. Turkish plants to be investigated are Colchicum szovitskii and several members of the _________ __________ Asclepiadaceae family. The impetus for this research is the recent report (N.Y. Times, Nov. 1, 1987, p. 33) that colchicine itself has significantly extended the lives of cirrhosis victims and has even reversed the damage that cirrhosis does to the liver, and secondly, there is little current research on new Colchicum alkaloids in the U.S. _________ Scope: This project is designed to have the Turkish _____ collaborators identify and gather the natural plants in Turkey. They then extract, purify, identify and test the chemical compounds obtained. The research data and samples are sent to the U.S. principal investigator for further analysis. The Turkish scientists participate with their U.S. counterpart at Penn State University in this advanced testing and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.