Alkaloids from Turkish Plants

摘要叙述 描述：本项目支持科学合作 化学系的莫里斯·沙玛博士 宾夕法尼亚州立大学和博士Tekant Gozler和博士。 (Mrs)埃格大学药学院的Belkis Gozler， （爱琴海大学），伊兹密尔，土耳其。 这项研究是为了 是一个继续进行的研究，题为“生物碱， 土耳其植物”。 研究目的是分离和 描述新的和不寻常的天然产品，特别是 生物碱，从植物来源。 获得的新化合物将 筛选药理学活性，如果在 足够大的数量。 此外，小说自然 分离的产物可能为生物遗传学提供新的见解。 发生在植物中的过程。 土耳其植物将成为 调查是秋水仙属szovitskii和几个成员的 _________ __________ 萝摩科。 这项研究的动力是 最近的报告（纽约州）1987年11月1日，第33页），秋水仙素 它本身就显著延长了肝硬化患者的生命 甚至逆转了肝硬化对肝脏的损害 肝脏，其次，目前很少有新的研究 秋水仙碱在美国 _________ 范围：该项目旨在使土耳其 _____ 合作者在土耳其识别和收集天然植物。 然后他们提取、纯化、鉴定和测试化学物质 获得的化合物。 研究数据和样品被送往 美国首席研究员进行进一步分析。 的 土耳其科学家与美国同行一起参加了 宾夕法尼亚州立大学在这一先进的测试和数据 汇编。 促进国际交流， 科学知识的培训和使用 国家科学家实现了科学的主要目标 发展中国家计划。

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Tekant Gozler and Dr. (Mrs) Belkis Gozler of the Faculty of Pharmacy, Ege University, (University of the Aegean), Izmir, Turkey. The research is to be a continuation of on going research entitled "Alkaloids for Turkish Plants". The research objectives are to isolate and characterize new and unusual natural products, particularly alkaloids, from plant sources. New compounds obtained will be screened for pharmacological activity, if obtained in sufficiently large quantities. Additionally, the novel natural products isolated may furnish new insights into the biogenetic processes occurring in plants. Turkish plants to be investigated are Colchicum szovitskii and several members of the _________ __________ Asclepiadaceae family. The impetus for this research is the recent report (N.Y. Times, Nov. 1, 1987, p. 33) that colchicine itself has significantly extended the lives of cirrhosis victims and has even reversed the damage that cirrhosis does to the liver, and secondly, there is little current research on new Colchicum alkaloids in the U.S. _________ Scope: This project is designed to have the Turkish _____ collaborators identify and gather the natural plants in Turkey. They then extract, purify, identify and test the chemical compounds obtained. The research data and samples are sent to the U.S. principal investigator for further analysis. The Turkish scientists participate with their U.S. counterpart at Penn State University in this advanced testing and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.