Alkaloids from Turkish Plants

来自土耳其植物的生物碱

• 批准号: 8814406
• 负责人: Maurice Shamma
• 金额: $ 2万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8814406&HistoricalAwards=false
• 关键词: Alkaloids; Turkish; Plants

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Tekant Gozler and Dr. (Mrs) Belkis Gozler of the Faculty of Pharmacy, Ege University, (University of the Aegean), Izmir, Turkey. The research is to be a continuation of on going research entitled "Alkaloids for Turkish Plants". The research objectives are to isolate and characterize new and unusual natural products, particularly alkaloids, from plant sources. New compounds obtained will be screened for pharmacological activity, if obtained in sufficiently large quantities. Additionally, the novel natural products isolated may furnish new insights into the biogenetic processes occurring in plants. Turkish plants to be investigated are Colchicum szovitskii and several members of the _________ __________ Asclepiadaceae family. The impetus for this research is the recent report (N.Y. Times, Nov. 1, 1987, p. 33) that colchicine itself has significantly extended the lives of cirrhosis victims and has even reversed the damage that cirrhosis does to the liver, and secondly, there is little current research on new Colchicum alkaloids in the U.S. _________ Scope: This project is designed to have the Turkish _____ collaborators identify and gather the natural plants in Turkey. They then extract, purify, identify and test the chemical compounds obtained. The research data and samples are sent to the U.S. principal investigator for further analysis. The Turkish scientists participate with their U.S. counterpart at Penn State University in this advanced testing and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.

摘要叙述说明：该项目支持宾夕法尼亚州立大学化学系的Maurice Shamma博士以及EGE大学（EGE University of Ege University，Aegean）的EGE University（Aegean of Aegean）的Tekant Gozler博士和Tekant Gozler博士和（Mrs）Belkis Gozler博士。 这项研究是继续进行的题为“土耳其植物的生物碱”的研究。 研究目标是将新的和不寻常的天然产品（尤其是生物碱）与植物来源隔离和表征。 如果以足够数量的数量获得，获得的新化合物将进行药理学活性。 此外，新型的天然产物可以为植物中发生的生物遗传过程提供新的见解。 Turkish plants to be investigated are Colchicum szovitskii and several members of the _________ __________ Asclepiadaceae family. The impetus for this research is the recent report (N.Y. Times, Nov. 1, 1987, p. 33) that colchicine itself has significantly extended the lives of cirrhosis victims and has even reversed the damage that cirrhosis does to the liver, and secondly, there is little current research on new Colchicum alkaloids in the U.S. _________ Scope: This project is designed to have the Turkish _____ collaborators identify并在土耳其收集天然植物。 然后，他们提取，纯化，识别和测试获得的化合物。 研究数据和样本被发送给美国首席研究员进行进一步分析。 土耳其科学家与宾夕法尼亚州立大学的美国同行一起参加了该高级测试和数据汇编。 国际科学知识交流以及发展中国家的培训和使用的进步实现了发展中国家科学计划的主要目标。