Alkaloids from Turkish Plants

摘要：本项目支持美国宾夕法尼亚州立大学化学系Maurice Shamma博士与土耳其伊兹密尔埃格大学（爱琴海大学）药学院Tekant Gozler博士和Belkis Gozler博士（夫人）的科学合作。这项研究将继续进行题为“土耳其植物生物碱”的研究。研究目标是分离和表征新的和不寻常的天然产物，特别是生物碱，从植物来源。如果获得足够大的量，将对获得的新化合物进行药理活性筛选。此外，新的天然产物分离可能提供新的见解发生在植物的生物遗传过程。拟研究的土耳其植物有秋水仙（Colchicum szovitskii）和_________ __________ Asclepiadaceae家族的几个成员。这项研究的推动力是最近的一篇报道（纽约时报，1987年11月1日，第33页），该报道称秋水仙碱本身可以显著延长肝硬化患者的生命，甚至可以逆转肝硬化对肝脏造成的损害，其次，目前在美国对新的秋水仙生物碱的研究很少_________该项目旨在让土耳其_____合作者识别和收集土耳其的天然植物。然后他们提取、纯化、鉴定和测试得到的化合物。研究数据和样本被送到美国首席研究员进行进一步分析。土耳其科学家与宾夕法尼亚州立大学的美国同行一起参与了这项先进的测试和数据汇编。促进科学知识的国际交流，培养和利用发展中国家的科学家，是科学在发展中国家计划的一个主要目标。

ABSTRACT NARRATIVE Description: This project supports the scientific cooperation of Dr. Maurice Shamma of the Department of Chemistry of Pennsylvania State University and Dr. Tekant Gozler and Dr. (Mrs) Belkis Gozler of the Faculty of Pharmacy, Ege University, (University of the Aegean), Izmir, Turkey. The research is to be a continuation of on going research entitled "Alkaloids for Turkish Plants". The research objectives are to isolate and characterize new and unusual natural products, particularly alkaloids, from plant sources. New compounds obtained will be screened for pharmacological activity, if obtained in sufficiently large quantities. Additionally, the novel natural products isolated may furnish new insights into the biogenetic processes occurring in plants. Turkish plants to be investigated are Colchicum szovitskii and several members of the _________ __________ Asclepiadaceae family. The impetus for this research is the recent report (N.Y. Times, Nov. 1, 1987, p. 33) that colchicine itself has significantly extended the lives of cirrhosis victims and has even reversed the damage that cirrhosis does to the liver, and secondly, there is little current research on new Colchicum alkaloids in the U.S. _________ Scope: This project is designed to have the Turkish _____ collaborators identify and gather the natural plants in Turkey. They then extract, purify, identify and test the chemical compounds obtained. The research data and samples are sent to the U.S. principal investigator for further analysis. The Turkish scientists participate with their U.S. counterpart at Penn State University in this advanced testing and data compilation. The advancement of the international exchange of scientific knowledge and the training and use of developing countries scientists fulfills a major objective of the Science in Developing Countries Program.