U.S.-Japan Cooperative Research: Fatty Acid Composition in Blood Lipids

美日合作研究：血脂中的脂肪酸组成

• 批准号: 8816318
• 负责人: William Lands
• 金额: $ 0.97万
• 依托单位: University of Illinois at Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1991-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8816318&HistoricalAwards=false
• 关键词: U.S.; Japan; Cooperative; Research; Fatty

This award will enable Prof. William E. Lands of the University of Illinois at Chicago to collaborate over a period of two years with Prof. Tomohito Hamazaki of the Toyama Medical and Pharmaceutical Univ- ersity and Professor Harumi Okuyama of the Nagoya City University, both in Japan. They will investigate whether or not analysis of the fatty acid composition of blood lipid can provide a reliable index of a person's tendency to ingest certain types of polyunsaturated fatty acids. Six different types of blood lipids, each of which responds at a different rate to changes in diet, are accessible for study, and the researchers will attempt to establish a definite relationship between the composition of an individual's diet and the composition of the various blood lipids. The purpose of this research is to obtain data on blood lipid composition as a function of diet, and to this end groups of Japanese, among whom there is a wide range of fat intake, will be given selected diets containing various ratios of fish and fat, various types of fat, or a special diet developed at the University of Illinois at Chicago. These controlled diet studies will allow quantification of the relationship of blood lipid composition to diet, making it possible eventually to eliminate the vagaries of dietary recall from diagnosis of individual dietary problems. Collaborative interactive teams of biochemists and nutritionists have been formed at each university involved with this project. These workers will share common techniques, reagents, and internal standards to ensure comparability of the data obtained. Collaboration with Japanese workers is essential to realize the full advantage of the variety found in the Japanese diet. This work has major implications in the realm of dietary diagnosis and health improvement and maintenance.

该奖项将使芝加哥伊利诺伊大学的William E. Lands教授能够与日本富山医药大学的Tomohito Hamazaki教授和名古屋城市大学的Harumi Okuyama教授进行为期两年的合作。他们将研究对血脂中脂肪酸组成的分析是否能提供一个可靠的指标，说明一个人摄入某些类型的多不饱和脂肪酸的倾向。六种不同类型的血脂，每一种都以不同的速度对饮食变化作出反应，可供研究，研究人员将试图建立一个明确的个人饮食组成和各种血脂组成之间的关系。这项研究的目的是获得血脂组成作为饮食功能的数据，为此目的，日本人的脂肪摄入量范围很广泛，他们将选择含有各种鱼和脂肪比例的饮食，各种类型的脂肪，或由伊利诺伊大学芝加哥分校开发的特殊饮食。这些控制饮食的研究将使血脂组成与饮食之间的关系量化，从而有可能最终消除个体饮食问题诊断中饮食回忆的变幻莫测。参与该项目的每一所大学都成立了由生物化学家和营养学家组成的协作互动小组。这些工作人员将共享共同的技术、试剂和内部标准，以确保所获得数据的可比性。要充分发挥日本饮食多样性的优势，与日本工人的合作至关重要。这项工作在饮食诊断和健康改善和维持领域具有重大意义。