Population and Biochemical Aspects of D. melanogaster G6PD.
黑腹果蝇 G6PD 的种群和生化方面。
基本信息
- 批准号:8818909
- 负责人:
- 金额:$ 14.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-01-15 至 1990-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This research will examine how two mutant enzyme variants, found in natural populations, influence an important metabolic pathway. As a model system the study focuses on the enzyme glucose-6-phosphate dehydrogenase (G6PD) in the fruit fly, Drosophila melanogaster. Prior studies have indicated significant differences in biochemical properties, but it is unclear that these differences as determined in the test tube in vitro reflect how the genetic variants function in the living fly (in vivo). This question will be addressed by examining the amount of radioactively labelled glucose passed through the metabolic pathway in flies possessing either genetic variant of the enzyme. This test is essential to our understanding of naturally occurring enzyme variation because it is usually assumed that there is a one-to-one correspondence between artificial in vitro measures of biochemical function and their function in vivo. However, no direct experiments have ever been conducted to test this assumption. This is the crucial experimental examination of that assumption in one of the very few systems where it may be directly tested.
本研究将研究在自然种群中发现的两种突变酶变体如何影响重要的代谢途径。作为一个模型系统,研究重点是果蝇葡萄糖-6-磷酸脱氢酶(G6PD)。先前的研究已经表明了生物化学特性的显著差异,但尚不清楚这些在试管中确定的差异是否反映了遗传变异在活蝇(体内)中的功能。这个问题将通过检查放射性标记葡萄糖的量通过代谢途径在苍蝇具有任何遗传变异的酶来解决。这个测试对于我们理解自然发生的酶变异是至关重要的,因为通常认为人工的体外生化功能测量与其体内功能之间存在一对一的对应关系。然而,还没有直接的实验来验证这一假设。这是对这一假设的关键实验检验,在少数几个可以直接检验的系统之一。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Walter Eanes其他文献
Walter Eanes的其他文献
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{{ truncateString('Walter Eanes', 18)}}的其他基金
Dissertation Research: Genetic Architecture of Adaptive Evolution in Mitochondrial Physiology
论文研究:线粒体生理学适应性进化的遗传结构
- 批准号:
1407000 - 财政年份:2014
- 资助金额:
$ 14.47万 - 项目类别:
Standard Grant
The Glycolytic Pathway and the Physiological Genetics of Flight Metabolism
糖酵解途径和飞行代谢的生理遗传学
- 批准号:
0920381 - 财政年份:2009
- 资助金额:
$ 14.47万 - 项目类别:
Standard Grant
COLLABORATIVE RESEARCH: Evolutionary dynamics of a molecular polymorphism for diapause and life histories in Drosophila melanogaster
合作研究:果蝇滞育和生活史分子多态性的进化动力学
- 批准号:
0921371 - 财政年份:2009
- 资助金额:
$ 14.47万 - 项目类别:
Standard Grant
COLLABORATIVE RESEARCH: Evolutionary Dynamics and Molecular Analysis of Reproductive Diapause in Drosophila Melanogaster
合作研究:果蝇生殖滞育的进化动力学和分子分析
- 批准号:
0543050 - 财政年份:2006
- 资助金额:
$ 14.47万 - 项目类别:
Standard Grant
Dissertation Research: Protein Variation and Structure-Function Relationships of the Metabolic Enzyme PGM of Drosophila
论文研究:果蝇代谢酶PGM的蛋白质变异及构效关系
- 批准号:
9902327 - 财政年份:1999
- 资助金额:
$ 14.47万 - 项目类别:
Standard Grant
Dissertation Research: Molecular Variation in Two Circumpolar Sea Urchins
论文研究:两种环极海胆的分子变异
- 批准号:
9423662 - 财政年份:1995
- 资助金额:
$ 14.47万 - 项目类别:
Standard Grant
Molecular Population Genetics of Inversion Polymorphism
反转多态性的分子群体遗传学
- 批准号:
9318381 - 财政年份:1994
- 资助金额:
$ 14.47万 - 项目类别:
Continuing Grant
Population and Biochemical Aspects of D. melanogaster G6PD
黑腹果蝇 G6PD 的种群和生化方面
- 批准号:
9007391 - 财政年份:1990
- 资助金额:
$ 14.47万 - 项目类别:
Continuing Grant
Genetics of Host Affiliation in Herbivorous Beetles (Chrysomelidae)
草食性甲虫(叶甲科)宿主的遗传学
- 批准号:
8817912 - 财政年份:1989
- 资助金额:
$ 14.47万 - 项目类别:
Continuing Grant
Population and Biochemical Aspects of D. Melanogaster G6PD
黑腹果蝇 G6PD 的种群和生化方面
- 批准号:
8500461 - 财政年份:1985
- 资助金额:
$ 14.47万 - 项目类别:
Standard Grant
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