Population and Biochemical Aspects of D. melanogaster G6PD

黑腹果蝇 G6PD 的种群和生化方面

• 批准号: 9007391
• 负责人: Walter Eanes
• 金额: $ 33万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-10-15 至 1994-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9007391&HistoricalAwards=false
• 关键词: Population; Biochemical; Aspects; D.; melanogaster

The objective of the planned research is to examine whether there is evidence, reflected in DNA sequences, that natural selection has played a role in the long term evolutionary persistence of two mutant enzyme variants. As a model system that study focuses on the essential metabolic enzyme, glucose-6- phosphate dehydrogenase, in the fly, Drosophila melanogaster. Earlier studies indicated that there are significant differences in the biochemical propoerties associated with the common genetic variants, but it is not clear if these differences contribute to the long-term evolutionary fate of the polymorphism in natural populations. Current advances in the mathematical theory of DNA sequence evolution predict very specific patterns will be associated with genetic polymorphism that have been maintained in populations for long periods of time because of natural selection. This model system presents the opportunity to apply this new theory. Such studies are essential if we are to understand the forces that effect the genetic variation which is ubiquitous in natural populations of all species, including humans, and it will also help us to understand the forces shaping DNA sequence variation.

计划中的研究的目的是审查是否 有证据表明，在DNA序列中， 自然选择在长期进化过程中发挥了作用 两种突变酶变体的持久性。 作为模型系统 这项研究的重点是基本的代谢酶，葡萄糖-6-， 磷酸脱氢酶，在果蝇中。 早期的研究表明， 在生化特性与共同的 遗传变异，但目前尚不清楚这些差异是否 有助于多态性的长期进化命运 在自然人群中。 数学的最新进展 DNA序列进化理论预测了非常特殊的模式 将与遗传多态性有关， 在人群中维持了很长一段时间， 自然选择 该模型系统提供了机会， 应用这个新理论。 如果我们要在全球范围内 理解影响遗传变异的力量， 普遍存在于所有物种的自然种群中，包括 这也将帮助我们理解塑造人类的力量， DNA序列变异。