Hitting bacteria with a Bam: Lectin-Like Antimicrobials as New Antibiotics

用 Bam 击中细菌：凝集素类抗菌剂作为新型抗生素

• 批准号: DP230102150
• 负责人: Dr Rhys Grinter
• 金额: $ 43.56万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102150
• 关键词: Hitting; bacteria; Bam; Lectin; Like

Antibiotic resistance in disease-causing bacteria is a rapidly growing problem, making the development of new antibiotics of critical importance. This project aims to develop naturally produced lectin-like protein antibiotics as novel antimicrobial agents. To achieve this, the project will produce an extensive library of these antibiotics and test them for potency and specificity. Using cutting-edge techniques, it will determine how these antibiotics kill cells on a molecular and cellular level. It is anticipated this research will create the tools and knowledge required to exploit lectin-like protein antibiotics to fight bacterial infection, which will lead to their use in the prevention of crop and livestock losses due to disease.

致病细菌的抗生素耐药性是一个迅速增长的问题，使得开发新的抗生素至关重要。本项目旨在开发天然产生的凝集素样蛋白抗生素作为新型抗菌剂。为了实现这一目标，该项目将产生一个广泛的抗生素库，并测试它们的效力和特异性。使用尖端技术，它将确定这些抗生素如何在分子和细胞水平上杀死细胞。预计这项研究将创造利用凝集素样蛋白抗生素对抗细菌感染所需的工具和知识，这将导致它们用于预防因疾病造成的作物和牲畜损失。