Computing Resource for Sequence Analysis

要求支持校园范围内的计算设施，该设施将用于提供对序列分析程序和序列数据库的访问。该设施将为理学院、医学院和农学院的20多个已获资助、正在进行的基础科学研究项目提供支持。这些项目中有很多都需要在计算机上存储序列，通过序列比对和模式查找方法对序列进行分析，从数据库中检索序列，以及从序列中预测蛋白质或RNA的二级结构。虽然简单类型的序列分析通常在实验室的微型计算机上进行，但亚利桑那大学的实验室还没有准备好访问更复杂类型的程序或序列数据库。这个问题最可行的解决方案是提供一个共享的计算设施，配备一套软件包，如威斯康星DNA序列分析程序，它将提供大部分所需的程序和数据库。拟议的设施将通过直接电缆或电话调制解调器提供计算机接入，并将与现有的计算系统联网。

Support is requested for a campus-wide computing facility which will be used to provide access to sequence analysis programs and sequence databases. This facility will support more than 20 funded, on-going, basic science research projects in the Colleges of Science, Medicine and Agriculture. A large variety of these projects require storage of sequences on the computer, analysis of sequences by sequence alignment and pattern finding methods, retrieval of sequences from databases, and prediction of secondary structure of proteins or RNA from their sequence. Although simple types of sequences analysis are routinely performed on laboratory microcomputers, laboratories at the University of Arizona do not have ready access to more complex types of programs or sequences databases. The most feasible solution to this problem is to provide a shared computing facility equipped with a set of software packages such as the Wisconsin DNA sequence analysis programs, which will provide most of the required programs and databases. The proposed facility will provide computer access by direct cable or a telephone modem, and will be net worked to an existing computing system.