UniProt: A centralized protein sequence and function resource

描述(由申请人提供)：UniProt联盟的长期目标是通过加强UniProt知识库(UniProtKB)并确保UniProt中的多样化信息将通过利用一系列传播策略为广泛的科学用户群所用，提供一个集中管理的、准确的、稳定的和全面的蛋白质序列和功能资源。这一目标将使生物医学研究领域有新的科学发现，从而改善人类健康。该项目的具体目标是：1。通过人工整理科学文献，提供与蛋白质相关的实验信息。这将通过识别和整理新的实验特征蛋白质以及更新现有蛋白质以获取新信息来实现。将扩大与其他人工管理资源的互动，并使用社区标准接口。2.自动注释实验中未表征的蛋白质，增加覆盖面和深度。这将提高指数增长的蛋白质序列空间的价值，并允许纠正错误信息。UniProt基于规则的系统将向社区提供。3.充当蛋白质信息的全球中心枢纽。这将通过以下方式实现：利用来自其他资源的数据作为输入或链接/可视化，并对数据进行组织，以便以最佳方式使用和导航。新的数据类型将在可用时包括在内，技术基础设施将随着蛋白质序列的持续增长而发展。4.维护和进一步发展UniProt的网站和其他服务。为此，将创建或纳入来自其他资源的专门可视化，以获得更直观和更好的概览，并提供适当的网络服务和格式，以便利提取UniProt的丰富数据。5.积极向现有和新用户社区寻求用户反馈，并为其提供培训。指定的用户体验测试和新用户社区的参与将有助于确定未来的方向。目标研究社区包括从事遗传变异工作的研究人员、医学研究人员和临床医生、细胞生物学家和药物发现/制药研究人员。 相关性：UniProt联合会生产的数据库通过收集和丰富基因组学和蛋白质组学项目的数据以及个别研究人员发表的结果，为研究人员提供了获取蛋白质序列和功能的综合途径。这是使基因组学和蛋白质组学研究成果易于获取的关键一步，以支持学术界和工业界的生物医学研究，从而促进制定预防和治疗人类健康的战略。

DESCRIPTION (provided by applicant): The long-term objective of the UniProt Consortium is to provide a centralized curated, accurate, stable, and comprehensive protein sequence and function resource by enhancing the UniProt Knowledgebase (UniProtKB) and ensuring that the diverse information in UniProt will be of use to a broad scientific user community by exploiting a range of dissemination strategies. This objective will enable new scientific discoveries in the fields of biomedical research that will enhance human health. The specific aims of the project are: 1. To provide the experimental information associated with proteins through manual curation of the scientific literature. This will be achieved by identifying and curating newly experimentally characterized proteins and by updating existing proteins for new information. Interaction with other manually curated resources will be extended, and community standard interfaces used. 2. To automatically annotate experimentally uncharacterized proteins, increasing both coverage and depth. This will enhance the value of the exponentially growing protein sequence space and allow for the correction of erroneous information. UniProt's rule based system will be made available to the community. 3. To act as the global central hub for protein information. This will be achieved by leveraging data from other resources either as imports or as links/visualization and organizing the data for its optimum use and navigation. New data types will be included as they become available, and the technical infrastructure will be developed to scale with the continued growth in protein sequences. 4. To maintain and further develop UniProt's website and other services. This will be done by creating or incorporating specialized visualizations from other resources for a more intuitive and better overview, and by providing appropriate web services and formats to facilitate the extraction of UniProt's rich data. 5. To actively seek user feedback from and provide training for existing and new user communities. Designated user experience testing and the engagement of new user communities will help to define future directions. Target research communities include researchers working on genetic variation, medical researchers and clinicians, cell biologists and drug discovery/ pharmaceutical researchers. RELEVANCE: The databases produced by the UniProt Consortium provide researchers with an integrated access to protein sequence and function by gathering and enriching data from genomics and proteomics projects as well as the results published by individual researchers. This is a crucial step in making genomics and proteomics research results easily accessible to support biomedical research in academia and industry and hence facilitate the development of preventive and curative strategies for human health.