Structure and Reactivity of Mixed Aggregates of Lithium Alkyls and Alkoxides

烷基锂和醇盐混合聚集体的结构和反应性

• 批准号: 8821554
• 负责人: Craig Ogle
• 金额: $ 10.93万
• 依托单位: University of North Carolina at Charlotte
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1993-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8821554&HistoricalAwards=false
• 关键词: Structure; Reactivity; Mixed; Aggregates; Lithium

This project by Craig Ogle of the University of North Carolina, Charlotte is within the Organic Dynamics Program, and is aimed at a better understanding of organolithium compounds. Organolithiums are important intermediates in the synthesis of a wide variety of organic compounds, and this research will provide the elucidation of their structure by a relatively new technique known as rapid injection nuclear magnetic resonance spectroscopy. The reactivity of alkyllithium reagents is often modified by the addition of alkoxides. Mixed bases have been used extensively in metalations, polymerizations and alkylations, without a clear understanding of how the reagent is being changed. This study is aimed at providing a fundamental understanding of the mechanism of the reaction of alkyllithiums and mixed aggregates with electrophiles; this may lead to the development of more reactive and selective reagents. The work will consist of the preparation and identification of mixed aggregates of organolithiums and alkoxides of groups IA and IIA. The reactivity of these mixed aggregates towards electrophiles and carbon acids will then be investigated by Li-7 and H-1 rapid injection NMR. Mixed aggregates formed from the reaction of alkyllithiums with electrophiles will also be investigated.

这个项目由北卡罗来纳州大学的克雷格奥格尔负责， 夏洛特是在有机动力学计划，并旨在 更好地理解有机锂化合物。 有机锂是合成有机锂的重要中间体， 各种各样的有机化合物，这项研究将 通过一种相对较新的方法来阐明它们的结构， 称为快速注入核磁共振技术 谱 烷基锂试剂的反应性通常通过以下方式改性： 添加醇盐。 混合碱已被使用 广泛用于金属化、聚合和烷基化， 如果不清楚试剂是如何 变了 这项研究旨在提供一个基本的 对烷基锂反应机理的理解 以及与亲电体混合的聚集体;这可能导致 开发更具反应性和选择性的试剂。 工作 将包括准备和确定混合的 IA族有机锂和醇盐的聚集体， IIA.这些混合骨料的反应性， 然后将由以下人员研究亲电体和碳酸 Li-7和H-1快速注入NMR。 混合骨料形成于 烷基锂与亲电试剂的反应也将 研究了