RUI: Rapid Injection NMR Studies of Conjugate Addition Reactions of Carbanionic Species

通过这项本科院校研究(RUI)奖，有机和高分子项目支持北卡罗来纳大学夏洛特分校化学系的Craig A.Oger教授和Michael D.Murphy博士的研究。该项目将应用核磁共振波谱和快速注入核磁共振技术来研究两个非常重要的化学反应，即阴离子聚合和有机铜酸盐的加成反应。尽管这两种反应在科学上具有重大意义，在经济上也具有非常重要的意义，但关于它们的机制，仍有许多未解之谜。使用快速NRM技术将能够确定这些重要反应中的活性中间体的结构和性质。在有机化学和高分子化学项目的支持下，这个项目将培训本科生和硕士学生使用复杂的分析仪器和现代实验设计。这项研究的潜在经济影响可能是重大的，导致聚合物和制药行业的新产品和新方法。

With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Program supports the research of Professor Craig A. Ogle and Dr. Michael D. Murphy of the Department of Chemistry at the University of North Carolina, Charlotte, NC. The project will apply NMR spectroscopy and the rapid injection NMR technique to the study of two very important chemical reactions, anionic polymerization and the addition reactions of organocuprates. Although both of these reactions are scientifically significant and highly important economically, there are many consequential unanswered questions concerning their mechanism. The use of the rapid NRM technique will allow the determination of the structure and nature of the reactive intermediates in these important reactions. With support from the Organic and Macromolecular Chemistry Program, this project will train undergraduate and masters students in the use of sophisticated analytical instrumentation and modern experimental design. The potential economic impact of this research could be significant, leading to new products and methodologies in both the polymer and the pharmaceutical industry.