RUI: Rapid Injection NMR Studies of Conjugate Addition Reactions of Carbanionic Species

通过这项本科院校研究（RUI）奖，有机和大分子项目支持北卡罗来纳州夏洛特市北卡罗来纳大学化学系的Craig A. Ogle教授和Michael D. Murphy博士的研究。该项目将应用核磁共振波谱和快速注入核磁共振技术来研究两个非常重要的化学反应，阴离子聚合和有机酸盐的加成反应。尽管这两种反应在科学上和经济上都具有重要意义，但关于它们的机理，仍有许多后续的未解之谜。使用快速NRM技术可以确定这些重要反应中反应中间体的结构和性质。在有机与大分子化学专业的支持下，本项目将培养本科生和硕士生使用先进的分析仪器和现代实验设计。这项研究的潜在经济影响可能是显著的，导致新的产品和方法在聚合物和制药工业。

With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Program supports the research of Professor Craig A. Ogle and Dr. Michael D. Murphy of the Department of Chemistry at the University of North Carolina, Charlotte, NC. The project will apply NMR spectroscopy and the rapid injection NMR technique to the study of two very important chemical reactions, anionic polymerization and the addition reactions of organocuprates. Although both of these reactions are scientifically significant and highly important economically, there are many consequential unanswered questions concerning their mechanism. The use of the rapid NRM technique will allow the determination of the structure and nature of the reactive intermediates in these important reactions. With support from the Organic and Macromolecular Chemistry Program, this project will train undergraduate and masters students in the use of sophisticated analytical instrumentation and modern experimental design. The potential economic impact of this research could be significant, leading to new products and methodologies in both the polymer and the pharmaceutical industry.