Rapid Injection NMR Studies of Copper(I) and Copper(III) Organocuprates

有了这个奖项，有机和高分子化学计划支持教授克雷格A。作者声明：Michael D. Murphy博士，北卡罗来纳州-夏洛特大学，他将应用核磁共振光谱学和快速注入核磁共振（RINMR）技术来研究有机铜化合物的反应，这是一些最有价值的试剂，用于形成C-C键。以前，已经鉴定了有机铜酸盐化学中几种长期寻求的铜（III）中间体。这些已被表征并显示为有机铜酸盐反应化学中的中间体。在找到制备中间体的方法之后，将探索铜（III）化合物的反应化学。传统上，铜（I）酸盐具有丰富的合成化学，并且预期可能存在与这些铜（III）酸盐相关的非常丰富的合成化学。新的方法ofpreparing这些铜（III）化合物，其随后的反应，使用快速注射核磁共振，和他们的台式化学将进行探索。继续了解这些反应在一个深层次的机械水平将改善他们通过使有机铜酸酯的烷基化更有效的副反应少，并可能导致新的方式作出合理的变化的试剂和反应条件，使他们能够控制对映选择性。这一奖项从有机和高分子化学计划支持教授克雷格A。作者声明：Michael D.墨菲的北卡罗来纳州-夏洛特大学的研究将探讨铜（III）的化学铜酸盐，一类化合物，直到现在很大程度上是未知的，但应该很容易获得的合成化学家从共同的前体。教授克雷格和墨菲将继续使用RINMR技术与工业科学家的合作。该项目将提供本科生和研究生在空气敏感试剂的制备和处理，分析仪器的操作和实验设计方面的培训。学生还将有机会分析NMR光谱和动力学数据，与工业化学家互动，并在区域和国家会议上展示他们的数据。这项研究的经济影响可能是巨大的，可能会导致制药行业的新产品和新方法。

With this award, the Organic and Macromolecular Chemistry Program supports Professors Craig A. Ogle and Michael D. Murphy of the University of North Carolina- Charlotte who will apply NMR spectroscopy and the rapid injection NMR (RINMR) technique to study the reactions of organocopper compounds, which are some of the most valuable reagents for the formation of C-C bonds. Previously, several long sought after copper (III) intermediates in organocuprate chemistry have been identified. These have been characterized and shown to be intermediates in organocuprate reaction chemistry. Having found ways of preparing the intermediate, the reaction chemistry of copper (III) compounds will be explored. Traditionally, copper (I) cuprates have a rich synthetic chemistry and it is expected that there may be a very rich synthetic chemistry associated with these copper(III) cuprates. New ways ofpreparing these copper (III) compounds, their subsequent reactions using rapid injection NMR, and their bench-top chemistry will be explored. Continuing to understand these reactions at a deep mechanistic level will improve them by making the alkylation of organocuprates more efficient with less side reactions and may lead to new ways of making rational changes to the reagents and reaction conditions to allow them to be controlled enantioselectively. .This award from the Organic and Macromolecular Chemistry Program supports Professors Craig A. Ogle and Michael D. Murphy of the University of North Carolina- Charlotte whose research will explore the chemistry of copper(III) cuprates, a class of compounds that up until now were largely unknown but should be readily available to the synthetic chemist from common precursors. Professors Craig ands Murphy will continue their collaboration using the RINMR technique with industrial scientists. This project will offer the training of undergraduate and graduate students in the preparation and handling of air sensitive reagents, operation of analytical instrumentation, and experimental design. Students will also have opportunities to analyze NMR spectra and kinetic data, interact with an industrial chemist, and present their data at regional and national meetings. The economic impact of this research could be significant, potentially leading to new products and methodologies in the pharmaceutical industry.