Investigating the impact of beta-subunit interactions on voltage gated potassium channel regulation using unnatural amino acid mutagenesis and mass spectrometry.

使用非天然氨基酸诱变和质谱研究 β 亚基相互作用对电压门控钾通道调节的影响。

• 批准号: 269685
• 负责人: Murray Christopher I
• 金额: $ 9.83万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-10-01 至 2015-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=269685&lang=en
• 关键词: Biophysics; Cardiac Arrhythmia; Electrophysiology; Ion Channels; Mass Spectrometry; Pharmacology; Unnatual Amino Acids

A cardiac arrhythmia is an electrical disturbance in the heart, which can cause a wide variety of potentially life threatening conditions. The root of these disturbances is a malfunction in the protein channels that open and close to transmit the bioelect

心律失常是一种心脏电干扰，可导致多种潜在的危及生命的疾病。这些干扰的根源是蛋白质通道的故障，这些通道的打开和关闭是为了传递生物选择