Synthetic Studies in the Field of Natural Product Chemistry

天然产物化学领域的合成研究

• 批准号: 8909762
• 负责人: Yoshito Kishi
• 金额: $ 87.38万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 1994-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8909762&HistoricalAwards=false
• 关键词: Synthetic; Studies; Field; Natural; Product

The Synthetic Organic Program supports the work of Yoshito Kishi. Kishi, Professor of Chemistry at Harvard University, is involved with a broadly based program of natural products chemistry. Included is a continuation of work on the synthesis of palytoxin, one of the most complicated organic compounds known. As a consequence of these efforts, new approaches to examine the shapes of complex molecules, and answers to fundamental questions about factors controlling the shapes of sugars are being developed. New methods for understanding the phenomena of bioluminescence and syntheses of compounds responsible for natural bioluminescence are also being undertaken. The major objective of this work is to make significant contributions to organic chemistry through investigations into eight research topics including: the total synthesis of palytoxin, the local conformational analysis of palytoxin, the conformational analysis of C- and O- glycosides, preparation and chemistry of helical oligopeptides, bioluminescence chemistry of dinoflagellate and krill systems and the bioluminescence of mushroom systems.

合成有机计划支持岸吉藤的工作。岸信介是哈佛大学的化学教授，他参与了一个基础广泛的天然产品化学项目。其中包括一项合成羽衣藻毒素的持续工作，这是已知的最复杂的有机化合物之一。作为这些努力的结果，人们正在开发新的方法来研究复杂分子的形状，并回答有关控制糖形状的因素的基本问题。理解生物发光现象的新方法和与自然生物发光有关的化合物的合成也在进行。这项工作的主要目的是通过对八个研究课题的研究为有机化学做出重大贡献，这些研究课题包括：羽衣藻毒素的全合成、羽扇豆毒素的局部构象分析、C-和O-糖苷的构象分析、螺旋寡肽的制备和化学、甲藻和磷虾系统的生物发光化学和蘑菇系统的生物发光。