A Fundamental Engineering Approach to Integrated Bioproduct Recovery, Separation and Monitoring for Large Scale Protein Purification

大规模蛋白质纯化的综合生物产品回收、分离和监测的基本工程方法

• 批准号: 8912150
• 负责人: Michael Ladisch
• 金额: $ 89.23万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-12-15 至 1993-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8912150&HistoricalAwards=false
• 关键词: Fundamental; Engineering; Approach; Integrated; Bioproduct

The overall goal of this award is to continue developing a fundamental engineering knowledge base in separations technology applicable to the manufacturing of biological products on a large scale. Key components to this base include: new separation techniques; separation technologies combined into novel systems which fit special requirements of new bioreactor and cell culture production methods; and fundamental models for scale-up of recovery and purification techniques. This award will also seek to educate bioprocess engineers and scientists in the cross-disciplinary approaches needed for invention, development and operation of commercial-scale bioprocesses.

该奖项的总体目标是继续发展分离技术的基础工程知识基础，适用于大规模生产生物制品。该基地的关键组成部分包括：新的分离技术；分离技术结合成新的系统，以适应新的生物反应器和细胞培养生产方法的特殊要求；以及扩大回收和净化技术规模的基本模型。该奖项还将寻求在商业规模生物工艺的发明、开发和操作所需的跨学科方法方面，对生物工艺工程师和科学家进行教育。