Regulation of Gene Expression During Sporulation of BacillusSubtilis

枯草芽孢杆菌孢子形成过程中基因表达的调控

• 批准号: 8912323
• 负责人: Patrick Piggot
• 金额: $ 27万
• 依托单位: Temple University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-10-15 至 1993-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8912323&HistoricalAwards=false
• 关键词: Regulation; Gene; Expression; During; Sporulation

Bacterial spore formation is a primitive system of cellular differentiation. A systematic study is proposed aimed at identifying and investigating the roles of essential vegetative genes that are needed during spore formation, and at integrating information about essential genes with our knowledge of spo genes in the bacterium Bacillus subtilis. The study will focus on spoIIA, which codes for an RNA polymerase sigma factor, and genes that are likely to be involved in spore septum formation. It is proposed to search for essential genes that are directly or indirectly under the control of spoIIA, and to extend the search to include essential genes under the control of spoOH, which is associated with the start of sporulation. The Controls of two vegetative division genes, ftsA and ftsZ, will be analyzed as likely prototypes of essential genes that are needed during sporulation.

细菌孢子的形成是一个原始的细胞系统， 分化 提出了一项系统的研究，旨在 确定和调查必要的植物的作用 在孢子形成和整合过程中所需的基因 关于必需基因的信息与我们对spo 枯草芽孢杆菌中的基因。 该研究将重点关注 在spoIIA上，其编码RNA聚合酶σ因子，和 可能与孢子隔膜形成有关的基因。 有人建议寻找直接或间接影响基因表达的必需基因， 间接受斯波尔IA控制，并扩大搜索范围 包括spoOH控制下的必需基因， 与孢子形成的开始有关。 控制两个 营养分裂基因ftsA和ftsZ将被分析为 这些基因可能是人类发育过程中所需的基本基因的原型， 孢子形成