Synaptic Inputs to Supraoptic Nucleus

视上核的突触输入

• 批准号: 8919898
• 负责人: Mark Weiss
• 金额: $ 8.59万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-02-01 至 1991-10-01
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8919898&HistoricalAwards=false
• 关键词: Synaptic; Inputs; Supraoptic; Nucleus

The magnocellular neuroendocrine system is a very important region of the hypothalamus which is involved in control of uterine contractions during parturition, the milk let-down reflex, and maternal behavior via oxytocin as well as the regulation of fluid homeostasis, vasoconstriction, stress responses, and possibly memory via vasopressin. The release of oxytocin and vasopressin are governed by the activity of these large magnocellular neurons. Dr. Weiss will identify the inputs to these neurons in normal animals since it is likely that the afferents play an critical role in determining their activity. He will then examine the influence of lactation and water deprivation on these synaptic inputs. Discerning the synaptic plasticity following physiological stimuli will contribute greatly to our knowledge of how the brain organizes actions and maintains our vital functions. Given the relationship of this hypothalamic region to regulation of fluid balance and the cardiovascular system, basic research may lead to better understanding of the neural regulation of hypertension and heart disease which are a major cause of death in middle-age males in our society.

大细胞神经内分泌系统是一个非常重要的 下丘脑的一个区域，参与控制 分娩时子宫收缩，乳汁减少 反射和母性行为通过催产素以及 调节体液平衡、血管收缩、应激 反应，以及可能通过加压素的记忆。 释放 催产素和后叶加压素受这些活性的支配， 大细胞神经元 韦斯博士将识别输入 正常动物的这些神经元， 传入神经在决定它们的活动中起着关键作用。 然后他将研究哺乳和水的影响 剥夺这些突触输入。 识别突触 生理刺激后的可塑性将有助于 极大地提高了我们对大脑如何组织行为的认识， 维持我们的重要功能。 考虑到这件事与 下丘脑区域调节液体平衡和 心血管系统，基础研究可能会导致更好的 了解高血压和心脏的神经调节 疾病，这是中年男性死亡的主要原因， 我们的社会