DNA Fingerprinting and Paternity Assessment in Non-Human Primates

非人类灵长类动物的 DNA 指纹图谱和亲子鉴定

• 批准号: 8818405
• 负责人: Mark Weiss
• 金额: $ 7.75万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8818405&HistoricalAwards=false
• 关键词: DNA; Fingerprinting; Paternity; Assessment; Non

The genome (the total of all genes in an organism) is much more variable than was thought a decade or two ago. This variability has led to the testing of gene loci to determine those which demonstrate a large number of alleles, none of which occur at high frequency. Such loci are used as "fingerprints" to distinguish individuals from each other and, because of their heritability, they are exceptionally useful in determining paternity. Thus, DNA fingerprinting is a relatively new and innovative technique that allows for identifications of parentage with an unprecedented degree of statistical confidence. Using DNS fingerprinting the investigators will determine paternity within captive populations of several species of nonhuman primates, and from a zone of hybridization of two species of baboons. The data generated in this study will allow for more efficient management of primate colonies by avoiding inbreeding, and will provide a tool for the investigation of a variety of questions relating kinship and selection, kin selection, dominance and reproductive success. The ability to identify parentage, especially paternity, is important in the management of primate colonies, and in field research on nonhuman primates.

基因组（生物体中所有基因的总数）比十年或两年前认为的可变得多。 这种变异性导致了基因基因座的测试，以确定那些证明大量等位基因的基因座，而这些等位基因均未出现高频。 这样的基因座被用作“指纹”，以区分个体，并且由于其遗传力，它们在确定亲子鉴定方面非常有用。 因此，DNA指纹识别是一种相对较新的创新技术，可以以前所未有的统计信心来识别父母的身份。 使用DNS指纹识别研究人员将确定几种非人类灵长类动物的圈养种群中的亲子关系，以及从两种狒狒的杂交区域中。 这项研究中产生的数据将通过避免近亲繁殖来更有效地管理灵长类动物殖民地，并将为研究有关亲属关系和选择，亲属选择，优势和生殖成功的各种问题提供工具。 鉴定亲子群，尤其是亲子关系的能力在灵长类动物殖民地的管理以及对非人类灵长类动物的现场研究中很重要。