Organic Synthesis via Transition

这项研究得到了有机合成计划的支持。赫格德斯博士将继续开发基于过渡金属的试剂，作为高度选择性的合成工具。这项研究的科学意义在于，将开发出通用于有机合成的新的化学转化，将产生具有有趣的物理、生物和化学性质的新的有机化合物，并将开发各种杂环和碳环系统的有效合成方法。研究的总体目标是开发使用过渡金属络合物的新的合成方法，以允许有机官能团的新的反应模式。这将通过仔细研究所涉及的金属-有机物种的基本化学来实现，以允许开发有用的新的合成转化。如果可能，新开发的工艺将应用于复杂分子的合成。反应性有机中间体，如富电子的烯烃、手性烯胺、高度官能化的手性四元中心和推拉式联烯，将通过从金属络合物中生成，使它们常规地可用于合成。新开发的方法将用于合成具有生物活性的β-内酰胺(+)-硫霉素、手性叔醇，用于大环抗生素和聚醚抗生素、三喹烷和吡咯吲哚醌类化合物。

This research is being supported by the Organic Synthesis Program. Dr. Hegedus will continue his development of transition metal based reagents as highly selective synthetic tools. The scientific significance of the research is that new chemical transformations of general use for organic synthesis will be developed, that new organic compounds with interesting physical, biological, and chemical properties will be produced, and that efficient synthetic approaches to a variety of heterocyclic and carbocyclic systems will be developed. The overall objective of the research is to develop new synthetic methods using transition metal complexes to permit new modes of reactivity for organic functional groups. This will be achieved by careful study of the fundamental chemistry of the metal-organic species involved, to permit the development of useful, new synthetic transformations. The newly developed processes will be applied to the synthesis of complex molecules when possible. Reactive organic intermediates such as electron-rich ketenes, chiral enamides, highly functionalized chiral quarternary centers, and "push-pull" allenes, will be made routinely accessible and usable for synthesis by generating them from metal complexes. The newly developed methodology will be used to synthesize the biologically active beta-lactam (+)-thienamycin, chiral tertiary alcohols for incorporation into macrocyclic antibiotics and polyether antibiotics, triquinanes and pyrroloindoloquinones.