Organic Synthesis via Transition Metal Complex Chemistry

通过过渡金属配合物化学进行有机合成

• 批准号: 9224489
• 负责人: Louis Hegedus
• 金额: $ 64.25万
• 依托单位: Colorado State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1999-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9224489&HistoricalAwards=false
• 关键词: Organic; Synthesis; via; Transition; Metal

The focus of this research is the use of the photochemical generation of heteroatom ketenes by photolysis of chromium carbene complexes. Catalytic processes to prepare cyclobutanones and beta-lactams will be explored along with synthetic approaches to sterically hindered carbene complexes. Photochemical 2+2 and 3+2 cycloadditions will be used to afford beta-lactams and an efficient route to alpha-heteroatom stannanes, which will be used in Pd catalyzed reactions, will be developed. Optically active chromium carbene derived intermediates including ene carbamates, butenolides and tetraazamacrocyclic cyclams will be used for asymmetric synthesis. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. Louis S. Hegedus of the Department of Chemistry at Colorado State University. Professor Hegedus will focus his work on the development of new synthetic methods using transition metal complexes to permit new modes of reactivity for organic functional groups. Efficient synthetic approaches to a variety of heterocyclic and carbocyclic systems will be developed.

本研究的重点是利用卡宾铬络合物的光解生成杂原子酮。将探索制备环丁酮和β-内酰胺的催化方法，以及空间受阻卡宾络合物的合成方法。光化学2+2和3+2环加成反应将被用来合成β-内酰胺类化合物，并将开发一条合成α-杂原子锡烷的有效途径，用于钯催化的反应。光学活性的卡宾铬衍生中间体，包括氨基甲酸烯、丁烯内酯和四氮杂大环环，将用于不对称合成。%有了这个续约奖，合成有机计划正在支持科罗拉多州立大学化学系的Louis S.Hegedus博士的研究。赫格德斯教授将专注于开发新的合成方法，使用过渡金属络合物来允许有机官能团的新反应模式。将开发各种杂环和碳环系统的有效合成方法。