Biomolecular condensates in mRNA-regulation in germ cells

生殖细胞中 mRNA 调节的生物分子凝聚体

• 批准号: DP230101395
• 负责人: Dr Peter Boag
• 金额: $ 42.67万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101395
• 关键词: Biomolecular; condensates; mRNA; regulation; germ

This project aims to investigate how cells form microenvironments that are enriched for specific biological functions. Using a powerful combination of cutting-edge in vitro and in vivo experiments, the project will generate new knowledge in the emerging area of liquid-liquid phase separation. We will analyse the formation of germ granules that are required for fertility. The expected outcome is a transformational understanding of how liquid-liquid phase separation occurs in cells which, in the longer term, will have applications in biotechnology and disease treatment.

该项目旨在研究细胞如何形成为特定生物功能而丰富的微环境。利用体外和体内尖端实验的强大组合，该项目将在新兴的液-液相分离领域产生新的知识。我们将分析生育所需的细菌颗粒的形成。预期的结果是对细胞中液-液相分离如何发生的变革性理解，从长远来看，这将在生物技术和疾病治疗中得到应用。