Algorithms for the Building of Model Proteins Using Structural Homology

由于生物技术产业的创新， 序列数据的可用性正在不断增加， 率 由于从X射线获得的结构信息 晶体学或NMR分析的获得要慢得多， 有许多蛋白质对正在进行的研究至关重要， 哪些氨基酸序列是已知的，但原子坐标 都是可用的。 本研究旨在 开发方法来确定分子结构的一个 蛋白质仅基于其氨基酸序列及其 与其他蛋白质的相似性， 是已知的。 这些方法将被纳入一个 将作为商业广告出售的计算机程序 product.*//

Because of innovations in the biotechnology industry,protein sequence data is becoming available at an even increasing rate. Since structural information obtained from X-ray crystallography or NMR analysis is obtained much more slowly, there are many proteins critical to ongoing research for which amino acid sequences are known but atomic coordinates are available. The research proposed here is designed to develop methods to determine the molecular structure of a protein based only on its amino acid sequence and its similarity to other proteins for which Cartesian coordinates are known. These methods will then be incorporated into a computer program which will be sold as a commercial product.***//