Lytic transglycosylases as new antibacterial targets

裂解性转糖基酶作为新的抗菌靶点

• 批准号: 179116
• 负责人: Clarke Anthony J
• 金额: $ 40.52万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-03-01 至 2014-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=179116&lang=en
• 关键词: Autolysins; Bacteriol Physiology; Enzymology; Lytic Transglycosylases; New Antibiotic Tragets; Peptidoglycan Metabolism

The insoluble peptidoglycan (PG) sacculus encloses the cytoplasmic membrane of bacterial cells to maintain their structural integrity. This fact, together with its uniqueness to the bacterial cell, have made the enzymatic machinery responsible for the bi

不溶性肽聚糖（PG）球囊包围细菌细胞的细胞质膜，以保持其结构的完整性。 这一事实，再加上它对细菌细胞的独特性，使得酶机制负责生物降解。