Research Toward the Application of Real-Time Gas Electron Diffraction as a Detector for Open Tubular Capillary Gas Chromatography

实时气体电子衍射作为开管毛细管气相色谱检测器的应用研究

• 批准号: 9002677
• 负责人: John Ewbank
• 金额: $ 16.15万
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9002677&HistoricalAwards=false
• 关键词: Research; Toward; Application; Real; Time

We propose to investigate enhancements of real-time Gas Electron Diffraction (GED) leading to application of this structure-analytic technique to the detection of effluents from Open Tubular Capillary Gas Chromatography (OTC-GC) columns. Our group was the first to successfully detect diffracted electrons by a phosphor screen coupled to a photodiode array. Our procedures are unique in the use of multichannel detection to obtain direct real- time structural information on molecules in the vapor phase. Later, we identified improvements in design that extend serviceability of GED to the study of analytes leaving the column of a gas chromatograph. GED affords a universal detector with relatively uniform sensitivity for diverse molecular species. The most singular feature is that it yields information on the structural makeup of those species. By combining the two techniques, GC and GED, we have pioneered a new area of structural chromatography. We now propose detector enhancements aimed at extending the applicability of this new method from the current nanoliter requirement of sample size to the picoliter domain, which would enable investigations with OTC- GC. This tool may find considerable importance, potentially as a standard instrument for analytical applications. In addition, the detector enhancements will pay secondary benefits in other ongoing experiments: in determining the structures of transient species and in kinetic studies with time resolution in the nanosecond regime using real-time electron diffraction with pulsed electron beams.

我们建议研究实时气体电子衍射 (GED) 的增强功能，从而将这种结构分析技术应用于检测开管毛细管气相色谱 (OTC-GC) 柱的流出物。 我们的团队是第一个通过与光电二极管阵列耦合的荧光屏成功检测衍射电子的团队。 我们的程序的独特之处在于使用多通道检测来获取气相分子的直接实时结构信息。 后来，我们确定了设计改进，将 GED 的适用性扩展到对离开气相色谱仪色谱柱的分析物的研究。 GED 提供了一种通用检测器，对于不同的分子种类具有相对一致的灵敏度。 最独特的特征是它提供了有关这些物种的结构组成的信息。 通过结合 GC 和 GED 这两种技术，我们开创了结构色谱的新领域。 我们现在提出检测器增强功能，旨在将这种新方法的适用性从当前的纳升样品尺寸要求扩展到皮升范围，这将使 OTC-GC 的研究成为可能。 该工具可能非常重要，有可能作为分析应用的标准仪器。 此外，探测器的增强功能还将在其他正在进行的实验中带来次要好处：确定瞬态物质的结构，以及使用脉冲电子束的实时电子衍射进行纳秒级时间分辨率的动力学研究。