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The Rise of Molecular Biology: Roots in Protein Research and the Problematic Relationship to Biochemistry

分子生物学的兴起：蛋白质研究的根源以及与生物化学的有问题的关系

基本信息

批准号：
9003042
负责人：
Angela Creager
金额：
$ 2.8万
依托单位：
Fellowships
依托单位国家：
美国
项目类别：
Fellowship Award
财政年份：
1991
资助国家：
美国
起止时间：
1991-05-01 至 1992-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9003042&HistoricalAwards=false
关键词：
Rise Molecular Biology Roots Protein

项目摘要

Dr. Creager, a trained biochemist, is entering a postdoctoral training and research program at the History of Science Department of Harvard University. Working with Professor Everett Mendelsohn, she is investigating two questions relating to the emergence of molecular biology in this century. First, how did the preexisting program of research on proteins contribute to the ascension of molecular biology and how was that program changed by it? Physiologists and biochemists appropriated experimental methodology from the physical sciences before molecular biologists exploited this approach to answer fundamental questions in genetics. Dr. Creager is examining the development of this physico-chemical approach at the Physical Chemistry Laboratory at Harvard Medical School in the first decades of this century. Second, she is asking is the concept of the molecular biological revolution of the life sciences a suitable or accurate expression of the nature of scientific change in biology in this century. She is studying the relationship of molecular biology to the older field of biochemistry in order to assess whether molecular biology introduced a novel methodology or approach. Her investigations of whether developments in the life sciences in this century have been continuous or discontinuous with previous traditions should provide a basis for assessing the nature of scientific change in modern biology.

克里格博士是一位训练有素的生物化学家，科学史系的培训和研究项目来自哈佛大学。与埃弗雷特门德尔松教授合作，她正在调查两个与分子生物学在本世纪。第一，如何使先前存在的蛋白质研究计划有助于Ascension 分子生物学是如何改变这个程序的生理学家和生物化学家利用实验方法在分子生物学家利用用这种方法来回答遗传学中的基本问题。博士克里格正在研究这种物理化学的发展在哈佛医学院物理化学实验室学校在这个世纪的头几十年。第二，她要求是生命的分子生物学革命的概念科学的本质的适当或准确的表达生物学在这个世纪的科学变化。她正在研究分子生物学与更古老领域的关系生物化学来评估分子生物学引入了一种新的方法或途径。她的调查本世纪生命科学的发展是否与先前传统的连续或不连续应提供评估现代科学变革性质的基础生物学