Juvenile Hormone Suppression of a Hemolymph Protein at the mRNA Level

mRNA 水平上血淋巴蛋白的保幼激素抑制

• 批准号: 9005184
• 负责人: Grace Jones
• 金额: $ 26.62万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-15 至 1993-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9005184&HistoricalAwards=false
• 关键词: Juvenile; Hormone; Suppression; Hemolymph; Protein

The result of the experiments will be new and original data on the mechanisms of action of juvenile hormone (JH) suppress gene expression. The use of a protein which becomes highly expressed during metamorphosis as the model for study ensures that the findings will further our understanding of, and ability to disrupt, a fundamental and developmentally critical point of regulation of insect development. The occurrence and importance of JH in a wide range of invertebrate groups ensures that the results will have wide significance and applicability towards invertebrates. It is also probable that the results of such studies on juvenile hormone will have important implications for studies on the action of retinoic acid in regulation of vertebrate gene expression.

实验结果将是关于保幼激素（JH）抑制基因表达的作用机制的新的原始数据。使用在变态过程中高度表达的蛋白质作为研究模型，确保了这些发现将进一步加深我们对昆虫发育调节的基本和发育关键点的理解和破坏的能力。 JH 在广泛的无脊椎动物群体中的出现和重要性确保了结果对无脊椎动物具有广泛的意义和适用性。 保幼激素的此类研究结果也可能对视黄酸调节脊椎动物基因表达的作用的研究产生重要影响。