Long & Medium Term Research: Activation and Functionaliza- tion of Chlorocarbons

长期中期研究：激活和功能化 氯碳化合物 该奖项是根据长期计划提出的。 &在国外卓越中心的中期研究。 的 该计划旨在使美国科学家和工程师能够 在国外的研究机构进行长期研究， 证明卓越。 奖项提供了机会， 开展联合研究，以及使用独特或复杂的 实验设施、专业知识和实验条件 国外 这个奖项是由大卫博士赞助的。霍夫曼 哈佛大学将支持为期12个月的访问， Dr. Derk A.维尔达将与首席执行官约翰A。 奥斯本的研究所勒贝尔的大学>路易巴斯德 在斯特拉斯堡举行的关于“ 含氯氟烃。“氯碳化合物是一种相对惰性的 具有有用性质的化合物，例如 溶剂或有毒物质，如氯化芳烃（PCB）。 最近发现，一系列的络合物， Pd（0）在温和条件下会活化C-Cl键。 等 络合物还用作羰基化的催化剂， CH 2Cl 2和C6 H5 Cl。 把原来的工作转化为氯碳 激活将扩展到其他氯和多氯- 含有化合物。 研究人员将进行机械 研究，以更好地了解氯碳的过程， 激活发生。 他们将进一步研究 涉及这些系统的潜在催化反应。 一 可能感兴趣的反应是加氢脱氯， 将氯碳化合物转化为 芳香烃. CH 2Cl 2在CO，H2， 碱和钯络合物催化生成乙烯酮， 非常活泼的有机分子 研究人员将 在各种乙烯酮存在下研究该过程 阱. 他们将研究其他烯酮的生成， 原地。 他们应调查 用类似的方法破坏更强的碳氟键。 授标建议提供资金， 适当的，国际旅行，出国当地旅行， 津贴，家属津贴（如适用）和公寓 美国本土机构的行政津贴为250美元。

Long & Medium-Term Research: Activation and Functionalization of Chlorocarbons This award recommendation is made under the Program for Long & Medium-Term Research at Foreign Centers of Excellence. The program seeks to enable U.S. scientists and engineers to conduct long-term research abroad at research institutions of proven excellence. Awards provide opportunities for the conduct of joint research, and the use of unique or compli- mentary facilities, expertise and experimental conditions in foreign countries. This award for a proposal sponsored by Dr. David A. Hoffman of Harvard University will support a twelve-month visit to France by Dr. Derk A. Wierda to work with Professeur John A. Osborn of the Institut Le Bel of the Universit> Louis Pasteur in Strasbourg on "Activation and Functionalization of Chlorocarbons." Chlorocarbons form a relatively inert class of compounds with properties which can be useful, such as solvent, or noxious, such as chlorinated aromatics (PCBs). It has recently been discovered that a series of complexes of Pd(0) will activate C-Cl bonds under mild conditions. Such complexes also serve as catalysts for the carbonylation of CH2Cl2 and C6H5Cl. The original work into chlorocarbon activation will be extended to other chloro- and polychloro- containing compounds. The researchers will conduct mechanistic studies to better understand how the process of chlorocarbon activation occurs. The will perform further research into potential catalytics reactions involving these systems. One possible reaction of interest is hydrodechlorination, a process by which chlorocarbons would be transformed into hydrocarbons. Reaction of CH2Cl2 in the presence of CO, H2, base and palladium complex catalytically generates ketene, a very reactive organic molecule. The researchers will investigate this process in the presence of various ketene traps. They will examine generation of other ketenes in situ. They shall perform investigations into the possibility of breaking the much stronger C-F bonds by similar methods. The award recommendation provides funds to cover, as appropriate, international travel, local travel abroad, stipend, dependents' allowance if applicable, and a flat administrative allowance of $250 for the U.S. home institution.