Peptide-Grafted Materials for Cell-Adhesive and Growth- Promoting Substrates

用于细胞粘附和生长促进基质的肽接枝材料

• 批准号: 9009901
• 负责人: Jeffrey Hubbell
• 金额: $ 22.5万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-15 至 1994-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9009901&HistoricalAwards=false
• 关键词: Peptide; Grafted; Materials; Cell; Adhesive

A novel class of cell adhesion substrates has been developed and partially characterized. These materials contain covalently attached peptide ligands for cell-surface receptors, and the particular structure of these peptides is based on the structure of proteins, called cell adhesion molecules, that mediate cell adhesion. Such an approach to cell attachment substrates provides a significant engineering advantage in enhanced control, specificity, stability, and synthetic ease. These materials may have important applications in cell culture technology and biomedical materials technology.

已经发现了一类新的细胞粘附底物， 发展和部分特点。 这些材料 含有共价连接的肽配体， 细胞表面受体以及细胞表面受体的特殊结构 这些肽基于蛋白质的结构， 称为细胞粘附分子， 粘连 这种细胞附着基质的方法 提供了显著的工程优势， 控制、特异性、稳定性和合成容易性。 这些材料可能在电池中有重要的应用 培养技术和生物医学材料技术。