Biofunctional Gels for Tissue Engineering in the Peripheral Nerve

用于周围神经组织工程的生物功能凝胶

• 批准号: 9409455
• 负责人: Jeffrey Hubbell
• 金额: $ 16.62万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9409455&HistoricalAwards=false
• 关键词: Biofunctional; Gels; Tissue; Engineering; Peripheral

9409455 Hubbell This proposal is on research to develop biomaterials for tissue engineering of the peripheral nerve. These biomaterials are comprised of fibrin gels containing synthetic matrix attachment peptides to provide both neuro-conductive and neuro-inductive stimuli in order to enhance nerve regeneration. This research has three specific aims which are: (1) to characterize the stability of the immobilization of the peptides incorporated into fibrin; (2) to determine the bioactivity of the incorporated peptides; and (3) to examine the effect of peptide incorporation on in vivo peripheral nerve generation. This research could have impact on the treatment of human neurological disease. ***

9409455 Hubbell该提案是关于开发用于周围神经组织工程的生物材料的研究。 这些生物材料由含有合成基质附着肽的纤维蛋白凝胶组成，以提供神经传导和神经诱导刺激，从而增强神经再生。 本研究有三个具体的目的：（1）表征掺入纤维蛋白的肽的固定稳定性;（2）确定掺入的肽的生物活性;和（3）检查肽掺入对体内周围神经生成的影响。 这项研究可能对人类神经系统疾病的治疗产生影响。 ***