RUI: Ontogeny of Modulation of Dentate Granule Cell Excitability in the Freely-moving Rat

这是一个RUI的建议，让本科生参与神经生理学的研究。本项目记录自由活动大鼠在断奶前和断奶后海马细胞的变化。对配对电刺激的反应将用于表征所研究细胞的促进和抑制调节的发展。该项目的独特之处在于，可以通过使用未麻醉和自由运动的动物来获得行为的神经生理学相关性。这项研究将提高对成熟的基本生理学的理解，也将使工程本科生参与重要的生命科学研究。

This is a RUI proposal to involve undergraduate engineering students in neurophysiology research. The project is to record from cells of the hippocampus of freely-moving rats during the preweaning and postweaning periods. The responses to paired electrical stimulation will be used to characterize the development of facilitatory and inhibitory modulation of the studied cells. The proposed project is unique in that neurophysiological correlates of behavior can be obtained by the use of unanesthetized and freely moving animals. The research will lead to an improved understanding of the basic physiology of maturation, and it will also involve engineering undergraduates in significant life sciences research.