Bispectral and Paired-Pulse Analysis of the Ontogeny of Hippocampal Theta Rhythm in the Freely Moving Rat

我们要研究的主要假设是，在正常发育过程中，海马θ峰频率的成熟主要与齿状颗粒细胞活性调节的变化有关，而不是与CA1锥体细胞的细胞兴奋性改变有关。另一个有待验证的假设是，生物一致性指数是衡量海马活动发展过程中CA1与齿状回之间相互关系变化的有效指标。在先前的研究中，外科手术和记录技术被开发出来，可以定量检查齿状颗粒细胞群的抑制/促进调节的发展。建模技术将用于描述大鼠出生后早期（15-22天）发育期间海马脑电图的发育。这些研究有望提供有关海马神经系统之间相互作用的新知识，这些相互作用负责海马脑电图模式的产生，因为动物在出生后早期的发育过程中与环境相互作用。该结果将为探索行为动物神经回路的成熟和脑电图的发育模式提供新的方法。该项目通过积极参与外科和记录技术以及应用于生物学问题的定量和计算技术的发展，为本科生提供高质量的研究经验。＊＊＊

9509117 Bronzino The primary hypothesis to be investigated is that, during normal development, the maturation of peak hippocampal theta frequency is related primarily to changes in the modulation of dentate granule cell activity, and not due to alterations in cellular excitability of CA1 pyramidal cells. Another hypothesis to be tested is that the biocoherence index is an effective measure of the changing interrelationships that occur between CA1 and the dentate gyrus during development of hippocampal activity. In previous research surgical and recording techniques were developed that allow a quantitative examination of the development of inhibitory/facilitatory modulation of the dentate granule cell population. Modeling techniques will be used to characterize the development of the rat hippocampal EEG during the early postnatal (15-22 days) period of development. The studies are expected to provide new knowledge on the interactions that occur between hippocampal neural systems responsible for the generation of hippocampal EEG patters as the animal iteracts with its environment during the early postnatal period of development. The results will provide new approaches to probe questions related to the maturation of neural circuits and developmental patterns of the EEG in behaving animals. The project provides a high quality research experience to undergraduate students through their active participation in surgery and recording techniques and to the development of quantitative and computational techniques applied to problems in biology. ***