Bispectral and Paired-Pulse Analysis of the Ontogeny of Hippocampal Theta Rhythm in the Freely Moving Rat

自由活动大鼠海马 Theta 节律个体发育的双谱和成对脉冲分析

• 批准号: 9509117
• 负责人: Joseph Bronzino
• 金额: $ 9.06万
• 依托单位: Trinity College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-15 至 1997-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9509117&HistoricalAwards=false
• 关键词: Bispectral; Paired; Pulse; Analysis; Ontogeny

9509117 Bronzino The primary hypothesis to be investigated is that, during normal development, the maturation of peak hippocampal theta frequency is related primarily to changes in the modulation of dentate granule cell activity, and not due to alterations in cellular excitability of CA1 pyramidal cells. Another hypothesis to be tested is that the biocoherence index is an effective measure of the changing interrelationships that occur between CA1 and the dentate gyrus during development of hippocampal activity. In previous research surgical and recording techniques were developed that allow a quantitative examination of the development of inhibitory/facilitatory modulation of the dentate granule cell population. Modeling techniques will be used to characterize the development of the rat hippocampal EEG during the early postnatal (15-22 days) period of development. The studies are expected to provide new knowledge on the interactions that occur between hippocampal neural systems responsible for the generation of hippocampal EEG patters as the animal iteracts with its environment during the early postnatal period of development. The results will provide new approaches to probe questions related to the maturation of neural circuits and developmental patterns of the EEG in behaving animals. The project provides a high quality research experience to undergraduate students through their active participation in surgery and recording techniques and to the development of quantitative and computational techniques applied to problems in biology. ***

9509117 Bronzino研究的主要假设是，在正常发育过程中，海马theta峰频率的成熟主要与齿状颗粒细胞活性调节的变化有关，而不是由于CA 1锥体细胞的细胞兴奋性的改变。 另一个有待检验的假设是，生物相干指数是一个有效的措施之间发生的变化的相互关系，在海马活动的发展过程中，CA 1和齿状回。 在以前的研究中，手术和记录技术的发展，允许定量检查的抑制/促进调制的齿状颗粒细胞群的发展。 建模技术将用于表征大鼠海马EEG在出生后早期（15-22天）发育期间的发育。 这些研究预计将提供新的知识之间发生的相互作用，海马神经系统负责产生海马EEG模式的动物迭代与其环境在出生后早期的发展。 这些结果将为探索行为动物神经回路成熟和EEG发育模式相关问题提供新的方法。 该项目提供了一个高质量的研究经验，本科生通过他们积极参与手术和记录技术，并应用于生物学问题的定量和计算技术的发展。 ***