RUI: Frequency-Dependent Modulation of Hippocampal Neural Circuit in Freely Moving Rats

RUI：自由移动大鼠海马神经回路的频率依赖性调制

• 批准号: 0451285
• 负责人: Joseph Bronzino
• 金额: --
• 依托单位: Trinity College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0451285&HistoricalAwards=false
• 关键词: RUI; Frequency; Dependent; Modulation; Hippocampal

0451285BronzinoThis investigation will contribute to developing a clear understanding of how local neural circuits respond to various inputs in determining how information is processed globally in the brain. The hippocampal formation, a brain structure intimately involved in learning and memory processes, is involved and the proposed studies are designed to quantify the modulation of a specific neuronal circuit within the hippocampal formation when it is subjected to different inputs (i.e., tetanization paradigms with varying burst frequencies). The investigators hypothesis is that modulation of the dentate cellular response is dependent upon the "burst frequency" of the tetanization paradigm activating this neuronal circuit. This is important as the pattern of firing in the perforant path consists of trains of 4-6 action potentials occurring every 25 ms, thereby sending a bursting pattern of activation to the dentate granule cells of the hippocampal formation. Tetanization of the medial perforant path (one of the major input pathways to the hippocampal formation) has been shown to induce long-term potentiation (LTP) in the dentate granule cell layer. This neural circuit serves as the first leg in the hippocampal trisynaptic circuit and such modulation influences the gating of neuronal transmission into and through the hippocampal formation; it therefore may play an important role in the development of learning and memory both in early life and throughout adulthood. The investigation is a unique partnership of the fields of biomedical engineering and neurobiology, melding the approaches and techniques of both disciplines to provide important insights regarding the performance of neural circuits capable of modifying their responses as they mature. Results obtained from the experiments to be conducted are expected to have benefits beyond the immediate studies. First, the miniaturized stimulation and recording methodologies that are to be developed to record bioelectric data in the freely moving pre-weaning animal can be used by others in a wide variety of applications. Second, the data acquired can be utilized to extend this line of research in the future.

0451285 Bronzino这项研究将有助于发展一个清晰的理解如何局部神经回路响应各种输入，以确定如何在大脑中处理信息的全局。海马结构，一种与学习和记忆过程密切相关的脑结构，被涉及，并且所提出的研究被设计为量化海马结构内的特定神经元回路在受到不同输入时的调制（即，具有不同爆发频率的强直化范例）。研究者的假设是，齿状细胞反应的调节依赖于激活该神经元回路的强直化范例的“爆发频率”。这是重要的，因为在穿孔路径中的放电模式由每25 ms发生的4-6个动作电位的序列组成，从而向海马结构的齿状颗粒细胞发送突发激活模式。内侧穿通通路（海马结构的主要输入通路之一）的Tetanization已被证明可诱导齿状颗粒细胞层的长时程增强（LTP）。该神经回路作为海马三突触回路中的第一条腿，并且这种调制影响进入和通过海马结构的神经元传输的门控;因此，它可能在生命早期和整个成年期的学习和记忆的发展中发挥重要作用。这项研究是生物医学工程和神经生物学领域的独特合作伙伴关系，融合了两个学科的方法和技术，为能够在成熟时修改其反应的神经回路的性能提供了重要的见解。从即将进行的实验中获得的结果预计将具有超出直接研究的益处。首先，被开发用于记录自由移动的断奶前动物中的生物电数据的小型化刺激和记录方法可以被其他人用于各种各样的应用中。其次，所获得的数据可以用于在未来扩展这一研究领域。