Ontogeny of Modulation of Dentate Granule Cell Excitability in the Freely-Moving Rat

本研究项目将利用新开发的外科和记录技术来定量检查齿状颗粒细胞群的抑制/促进调节的个体发生。这些记录将在长期植入的、正常的、未断奶的大鼠身上进行。通过对穿孔通路的单脉冲和成对脉冲刺激，可以获得细胞外场电位。双谱分析和非高斯自回归建模技术将被用来描述出生后早期海马脑电图的发展。​这些研究将揭示在动物与环境相互作用过程中，负责产生海马脑电图模式的海马神经系统之间发生的相互作用早期：出生后的早期发育时期该结果将为探索行为动物神经回路的成熟和脑电图的发育模式提供新的方法。

This research project will utilize newly developed surgical and recording techniques to quantitatively examine the ontogeny of inhibitory/facilitatory modulation of the dentate granule cell population. The recordings will be done in chronically implanted, behaving, preweaned rats. Extracellular field potentials will be obtained in response to single- and paired- pulse stimulation of the perforant path. Bispectral analysis and non- Gaussian autoregressive modeling techniques will be used to characterize the development of the hippocampal EEG during the early postnatal period of development. These studies will shed new light on the interactions which occur between hippocampal neural systems responsible for the generation of hippocampal EEG patterns as the animal interacts with its environment during the early postnatal period of development. The results will provide new approaches to probe questions related to the maturation of neural circuits and developmental patterns of the EEG in behaving animals.