Ontogeny of Modulation of Dentate Granule Cell Excitability in the Freely-Moving Rat

自由移动大鼠齿状颗粒细胞兴奋性调节的个体发育

• 批准号: 9208128
• 负责人: Joseph Bronzino
• 金额: $ 21.89万
• 依托单位: Trinity College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9208128&HistoricalAwards=false
• 关键词: Ontogeny; Modulation; Dentate; Granule; Cell

This research project will utilize newly developed surgical and recording techniques to quantitatively examine the ontogeny of inhibitory/facilitatory modulation of the dentate granule cell population. The recordings will be done in chronically implanted, behaving, preweaned rats. Extracellular field potentials will be obtained in response to single- and paired- pulse stimulation of the perforant path. Bispectral analysis and non- Gaussian autoregressive modeling techniques will be used to characterize the development of the hippocampal EEG during the early postnatal period of development. These studies will shed new light on the interactions which occur between hippocampal neural systems responsible for the generation of hippocampal EEG patterns as the animal interacts with its environment during the early postnatal period of development. The results will provide new approaches to probe questions related to the maturation of neural circuits and developmental patterns of the EEG in behaving animals.

这项研究项目将利用新开发的外科手术和记录技术来定量检查抑制性/易化性的个体发生。对齿状颗粒细胞群的调节。记录将在长期植入的、行为正常的、预断奶的大鼠身上进行。细胞外场电位将响应于单脉冲和成对脉冲刺激穿孔路径而获得。将使用双谱分析和非高斯自回归建模技术来表征早期海马区脑电的发育后天发育期。这些研究将对负责产生海马脑电模式的海马神经系统之间的相互作用提供新的线索动物在出生后发育的早期阶段与环境相互作用。这一结果将为探索与行为动物的神经回路成熟和脑电发育模式相关的问题提供新的途径。