Proteases from Hyperthermophilic Archaebacteria: Physiolo- gical, Genetic, Biochemical and Engineering Studies
Proteases from Hyperthermophilic Archaebacteria: Physiolo- gical, Genetic, Biochemical and Engineering Studies
批准号:
9011583
负责人:
Robert Kelly
金额:
$41.29万
依托单位:
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-09-01 至 1992-09-01
中文摘要
能在100度或以上的温度下生长的细菌 摄氏度,即,超嗜热古细菌,只有 最近从各种地热中分离出来 地点 这里提出的工作涉及生理, 蛋白水解的遗传、生物化学和工程问题 由激烈火球菌产生的酶,其具有 最佳生长温度为100摄氏度。 初步研究将侧重于 使用超嗜热蛋白酶作为替代物 目前用于生化处理的那些。 在 此外,与热稳定性有关的问题 将研究热稳定蛋白酶, 确定功能的结构基础, 温度
英文摘要
Bacteria able to grow at temperatures at or above 100 degrees C, i.e., hyperthermophilic archaebacteria, have only recently been isolated from a variety of geothermal locations. The work proposed here addresses physiological, genetic, biochemical and engineering issues for proteolytic enzymes produced by Pyrococcus furiosus, which has an optimal growth at 100 degrees C. Initial studies will focus on the use of hyperthermophilic proteases as alternatives to those currently used in biochemical processing. In addition, issues related to the extreme thermostability of thermal stable proteases will be investigated to attempt to determine the structural basis for function at elevated temperatures.
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Population Growth and Human Behavioral Change
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批准号:1939019
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项目类别:Standard Grant
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资助金额:$9.44万
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财政年份:2020
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负责人:Robert Kelly
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依托单位:
Populating a Radiocarbon Database of North America, Phase III
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批准号:1822033
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项目类别:Standard Grant
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资助金额:$28.55万
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财政年份:2018
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负责人:Robert Kelly
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依托单位:
Leveraging Extreme Thermoacidophily for Bio-based Chemicals
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批准号:1802939
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项目类别:Standard Grant
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资助金额:$30.15万
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财政年份:2018
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负责人:Robert Kelly
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依托单位:
Populating a Radiocarbon Database of North American, Phase II
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批准号:1624061
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项目类别:Standard Grant
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资助金额:$26.19万
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财政年份:2016
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负责人:Robert Kelly
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依托单位:
Populating a Radiocarbon Database of Western North America
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批准号:1418858
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项目类别:Standard Grant
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资助金额:$25.49万
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财政年份:2014
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负责人:Robert Kelly
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依托单位:
COLLABORATIVE RESEARCH: Exploiting microbial hyperthermophilicity to produce an industrial chemical
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批准号:1264052
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项目类别:Standard Grant
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资助金额:$25.0万
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财政年份:2013
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负责人:Robert Kelly
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依托单位:
Doctoral Dissertation Improvement Grant: Testing Colonization Models in New England
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批准号:1342656
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项目类别:Standard Grant
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资助金额:$2.8万
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财政年份:2013
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负责人:Robert Kelly
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依托单位:
Human Occupation of the Bighorn Mountains
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批准号:0710868
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项目类别:Standard Grant
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资助金额:$6.02万
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财政年份:2007
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负责人:Robert Kelly
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依托单位:
Functional Approaches for Annotating Secretome-bound Small ORFs in Microbial Genomes
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批准号:0730091
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项目类别:Standard Grant
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资助金额:$31.88万
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财政年份:2007
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负责人:Robert Kelly
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依托单位:
Collaborative Research: Biotransformations Near and Above 100°C: Hyperthermophilic Microorganisms and Enzymes for Bioenergy Conversion
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批准号:0617272
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项目类别:Standard Grant
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资助金额:$42.04万
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财政年份:2006
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负责人:Robert Kelly
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依托单位:
LATE PLEISTOCENE HUMAN OCCUPATION OF THE BIGHORN MOUNTAINS
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批准号:0514863
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项目类别:Standard Grant
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资助金额:$0.0万
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财政年份:2005
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负责人:Robert Kelly
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依托单位:
Fluxes in Advective and Transition Boundary Layers
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批准号:0354819
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项目类别:Continuing Grant
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资助金额:$37.82万
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财政年份:2004
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负责人:Robert Kelly
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依托单位:
Biotransformations Near and Above 100 C: Mining Genomes of Hyperthermophiles for New Biocatalysts
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批准号:0317886
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项目类别:Continuing Grant
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资助金额:$40.0万
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财政年份:2003
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负责人:Robert Kelly
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依托单位:
Collaborative Research: Molecular and Engineering Studies of Extremely Thermophilic Xylose Isomerases
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批准号:0115734
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项目类别:Continuing Grant
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资助金额:$28.64万
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财政年份:2001
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负责人:Robert Kelly
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依托单位:
Biotransformations Near and Above 100 Degrees Celsius
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批准号:0000487
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项目类别:Continuing Grant
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资助金额:$24.99万
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财政年份:2000
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负责人:Robert Kelly
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依托单位:
Early Holocene Prehistory in the Intermontane West: Reinvestigation of the Pine Spring Site, Southwest Wyoming
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批准号:9973272
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项目类别:Standard Grant
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资助金额:$3.13万
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财政年份:1999
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负责人:Robert Kelly
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依托单位:
Engineering Foundation Conference on Enzyme Engineering XV, Oct. 15-19, 1999, Kona, Hawaii
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批准号:9904113
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项目类别:Standard Grant
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资助金额:$1.4万
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财政年份:1999
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负责人:Robert Kelly
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依托单位:
Microfabrication Methods Applied to the Development of Rigorously Defined Occluded Region Corrosion Samples
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批准号:9811412
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项目类别:Continuing Grant
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资助金额:$34.72万
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财政年份:1998
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负责人:Robert Kelly
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依托单位:
Biological and Chemical Energetics of Deep Sea Subsurface Life: Evolutionary and Exobiological Implications
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批准号:9816492
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项目类别:Standard Grant
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资助金额:$23.5万
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财政年份:1998
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负责人:Robert Kelly
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依托单位:
Collaborative Research: Biomolecular and Engineering Studies of Extremely Thermophilic Xylose (Glucose) Isomerases
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批准号:9817067
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项目类别:Continuing Grant
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资助金额:$24.49万
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财政年份:1998
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负责人:Robert Kelly
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依托单位:
海外基金