Adhesion, Deformation, and Fusion of Monolayers, Bilayers, and Membranes

单层、双层和膜的粘附、变形和融合

基本信息

项目摘要

In the first (two-year) research period, the roles of different interbilayer forces and bilayer fluidity on the molecular-scale deformations of adhering and fusing bilayer using novel electron microscopy and surface force measurements have been studied. These experiments identified a particularly important role for hydrophobic forces in adhesion and fusion. In this follow-up project, it is further proposed to study how hydrophobic, stearic, and ionic interactions operate at the molecular level. Various time-dependent effects associated with hydrophobic forces and adhesion are investigated. Lipid mixtures and lipid-protein membranes are used. The effects of fusion-inducing proteins, such as Synexin, are probed. The Surface Forces Apparatus will be used in parallel with a variety of Electron, scanning Tunneling, and Atomic Force Microscopy techniques. The results will be important in (i) developing the capability to directly study the interactions of real biological membranes and of other biological macromolecule; (ii) the development of chemicals and processes which can control adhesion or fusion of vesicles, liposomes, and biological cells in biotechnological processes; and (iii) the effectiveness of surfactant as dispersant, in flotation, in foams, and in emulsions.
在第一个(两年)研究期间,使用新型电子显微镜和表面力测量研究了不同双层间力和双层流动性对粘附和融合双层的分子尺度变形的作用。 这些实验确定了疏水力在粘附和融合中的特别重要的作用。 在这个后续项目中,进一步建议研究疏水性、硬脂酸和离子相互作用如何在分子水平上发挥作用。 研究了与疏水力和粘附力相关的各种时间依赖性效应。 使用脂质混合物和脂质-蛋白质膜。 探索了融合诱导蛋白(例如 Synexin)的作用。 表面力装置将与各种电子、扫描隧道和原子力显微镜技术并行使用。 这些结果对于(i)发展直接研究真实生物膜和其他生物大分子相互作用的能力非常重要; (ii) 开发能够控制生物技术过程中囊泡、脂质体和生物细胞粘附或融合的化学品和工艺; (iii) 表面活性剂作为分散剂在浮选、泡沫和乳液中的有效性。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Jacob Israelachvili其他文献

Confined fluids and their role in pressure solution
  • DOI:
    10.1016/j.chemgeo.2006.02.027
  • 发表时间:
    2006-06-22
  • 期刊:
  • 影响因子:
  • 作者:
    Alessandro Anzalone;James Boles;George Greene;Kevin Young;Jacob Israelachvili;Norma Alcantar
  • 通讯作者:
    Norma Alcantar
Role of hydration and water structure in biological and colloidal interactions
水合作用和水结构在生物和胶体相互作用中的作用
  • DOI:
    10.1038/379219a0
  • 发表时间:
    1996-01-18
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    Jacob Israelachvili;Håkan Wennerström
  • 通讯作者:
    Håkan Wennerström
Unravelling the Secrets of Catechol-Cation Binding Synergy
  • DOI:
    10.1016/j.bpj.2017.11.2961
  • 发表时间:
    2018-02-02
  • 期刊:
  • 影响因子:
  • 作者:
    George Degen;Jacob Israelachvili
  • 通讯作者:
    Jacob Israelachvili
The role of interparticle and external forces in nanoparticle assembly
粒子间和外力在纳米粒子组装中的作用
  • DOI:
    10.1038/nmat2206
  • 发表时间:
    2008-07-01
  • 期刊:
  • 影响因子:
    38.500
  • 作者:
    Younjin Min;Mustafa Akbulut;Kai Kristiansen;Yuval Golan;Jacob Israelachvili
  • 通讯作者:
    Jacob Israelachvili
Interaction Forces Between Model Myelin Membranes
  • DOI:
    10.1016/j.bpj.2010.12.3641
  • 发表时间:
    2011-02-02
  • 期刊:
  • 影响因子:
  • 作者:
    Xavier Banquy;Kai Kristianson;Dong Woog Lee;Joan Boggs;Cynthia Husted;Younjin Min;Joe Zasadzinski;Jacob Israelachvili
  • 通讯作者:
    Jacob Israelachvili

Jacob Israelachvili的其他文献

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{{ truncateString('Jacob Israelachvili', 18)}}的其他基金

Molecular and surface interactions in the 'directed' assembly of nano-structured inorganic-organic materials
纳米结构无机-有机材料“定向”组装中的分子和表面相互作用
  • 批准号:
    1059108
  • 财政年份:
    2011
  • 资助金额:
    $ 18万
  • 项目类别:
    Continuing Grant
NER: Controlled Processing and Electro-Optical Characterization of Nanoparticles and Conducting Organic Films via Mechanical Pressure, Shear and/or Rolling
NER:通过机械压力、剪切和/或滚动对纳米粒子和导电有机薄膜进行控制处理和电光表征
  • 批准号:
    0304671
  • 财政年份:
    2003
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant
GOALI: A GOALI Study of the Stability of Monolayers, Bilayers, and Multivesicular Lipsomes
GOALI:单层、双层和多囊泡脂质体稳定性的 GOALI 研究
  • 批准号:
    9634050
  • 财政年份:
    1997
  • 资助金额:
    $ 18万
  • 项目类别:
    Continuing Grant
Dynamic Studies of the Adhesion, Deformation and Fusion of Monolayers, Bilayers and Membranes
单层、双层和膜的粘附、变形和融合的动态研究
  • 批准号:
    9305868
  • 财政年份:
    1993
  • 资助金额:
    $ 18万
  • 项目类别:
    Continuing Grant
Adhesion Deformation and Fusion of Bilayer Vesicles and Other Amphiphilic Structures in Solution
溶液中双层囊泡和其他两亲结构的粘附变形和融合
  • 批准号:
    8721741
  • 财政年份:
    1988
  • 资助金额:
    $ 18万
  • 项目类别:
    Continuing Grant
Dynamic Processes in Complex Thin Fluid Films Between Solid Surfaces (Expedited Award)
固体表面之间复杂薄流体膜的动态过程(加急奖)
  • 批准号:
    8616599
  • 财政年份:
    1986
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant

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博士后奖学金:EAR-PF:晶粒尺度变形对氦扩散和副矿物热测年年龄的影响
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