The Design of Chiral Lewis Acids and Chiral Silane Reagents

该奖项将支持Tarek Sammakia博士的研究， 位于博尔德的科罗拉多大学。奖项是启动器 Sammakia博士博士后研究的资助部分 研究员在化学和处理的设计，合成， 手性刘易斯酸与手性硅烷的反应性 试剂 稳定的α-二茂铁基刘易斯酸碳阳离子将是 合成的手性中心低于表面， 活性碳正离子中心这些反应性中间体将 作为羟醛缩合中的立体中心， Michael加成反应和Diels-Alder反应。的 二茂铁模板也将用于合成手性 二茂铁基硅烷，将在不对称 酮的还原。

This award will support the research of Dr. Tarek Sammakia at the University of Colorado at Boulder. The award is the starter grant portion of Dr. Sammakia's Postdoctoral Research Fellowship in Chemistry and deals with the design, synthesis, and reactivity of chiral Lewis acids and chiral silane reagents. Stable alpha-ferrocenyl Lewis acid carbocations will be synthesized which have a chiral center below the face of the reactive carbonium center. These reactive intermediates will be evaluated as the stereogenic centers in aldol condensations, Michael addition reactions and Diels-Alder reactions. The ferrocene template will also be used to synthesize chiral ferrocenyl silanes which will be tested in the asymmetric reduction of ketones.