Spatial and Temporal Heterogeneity of Cerebral Blood Flow

脑血流的时空异质性

• 批准号: 9022190
• 负责人: Stephen Jones
• 金额: $ 14.29万
• 依托单位: Cleveland Clinic Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-15 至 1994-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9022190&HistoricalAwards=false
• 关键词: Spatial; Temporal; Heterogeneity; Cerebral; Blood

The architecture of the cerebral cortex of the brain shows sophisticated connections among and between the layers of nerve cells, and within and between functional units called columns. Nerve cells have very high metabolic rates, and blood flow to different areas of the brain depends on which parts are most active at particular times. Blood flow is altered by regional changes in oxygen and carbon dioxide content, as well as by blood pressure. It is known that vascular capillary networks show flow changes with regional, cyclic activity of opening and closing. The opening of a capillary network to a local region is called recruitment, and provides local cycling of nutrients (such as oxygen) and waste metabolites to active biological tissues. This work uses a unique approach to combine the concepts of temporal cycling, capillary recruitment, columnar organization of the cortex, and vascular architecture of the cortex. There are suggestions that the recruitment cycles here are relatively quite rapid. Measurements with novel technology will allow new results at a very fine level in time and space, to determine how vascular units composed of groups of capillaries regulate flow in response to demand. The impact of this novel work will be high not only on the obvious clinical issues, but on the many areas of neuroscience that deal with functional architecture and activity patterns in the brain.

大脑皮层的结构显示 神经层之间的复杂连接 单元，以及称为列的功能单元内和功能单元之间。 神经细胞有很高的代谢率，血液流向 大脑的不同区域取决于哪些部分最重要 在特定的时间活跃。 血液流动被局部的 氧气和二氧化碳含量的变化，以及血液 压力 众所周知，血管毛细血管网络显示流动 随着区域性的、周期性的开合活动而变化。 毛细血管网向局部区域的开放称为 补充，并提供营养物质的局部循环（如 氧）和代谢废物转化为活性生物组织。 这项工作采用了独特的方法，将联合收割机的概念， 时间循环，毛细血管募集，柱状组织， 皮层和皮层的血管结构。 有 这表明这里的招聘周期相对较长， 迅速。 新技术的测量将带来新的结果 在时间和空间的非常精细的水平上， 由毛细血管群组成的单位调节血流 要求。 这部小说的影响不仅会很大， 明显的临床问题，但在许多领域， 神经科学研究功能结构和活动 大脑中的模式