Safe and efficient biomedical nanomaterials

安全高效的生物医用纳米材料

• 批准号: DP170100511
• 负责人: Prof Irene Yarovsky
• 金额: $ 19.98万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-06-30 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100511
• 关键词: Safe; efficient; biomedical; nanomaterials

This project aims to rationally engineer nanomaterials with controlled biological responses. Nanomaterials are becoming widespread in biomedicine and engineering, but are inefficient and unsafe. This project will develop atomic scale models to understand interactions between engineered nanoparticles and the crowded cellular environment. It will design extremely sensitive biosensors and theranostic nanodevices combining medical imaging capacity with precision targeted drug delivery to improve efficiency and safety of nanomaterials for biomedical applications in both vitro and in vivo enabling cost effective early diagnostics and more efficient treatments.

该项目旨在合理设计具有受控生物反应的纳米材料。纳米材料在生物医学和工程中越来越普遍，但效率低下且不安全。该项目将开发原子尺度模型，以了解工程纳米粒子和拥挤的细胞环境之间的相互作用。它将设计极其敏感的生物传感器和治疗诊断纳米设备，将医学成像能力与精确的靶向药物输送相结合，以提高纳米材料在体外和体内生物医学应用中的效率和安全性，从而实现具有成本效益的早期诊断和更有效的治疗。