Protein self-assembly on surfaces, interfaces and nanoparticles

表面、界面和纳米粒子上的蛋白质自组装

• 批准号: DP0984565
• 负责人: Prof Irene Yarovsky
• 金额: $ 23.56万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-07-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984565
• 关键词: Protein; self; assembly; surfaces; interfaces

Surfaces such as those presented by an air-liquid interface or air-borne nanoparticles exert significant effects on protein aggregation in biological environments. We will develop a comprehensive theoretical and experimental approach to study the effects of such surfaces on the self assembly of proteins leading to disease causing amyloid fibrils. This will provide a molecular level understanding of protein self-association and a rational basis for the design of inhibitors to stop protein aggregation. The work will also establish design principles for new nanomaterials via the controlled self assembly of proteins on surfaces.

空气-液体界面或空气中的纳米粒子等表面对生物环境中的蛋白质聚集产生显着影响。 我们将开发一种全面的理论和实验方法来研究此类表面对导致淀粉样原纤维疾病的蛋白质自组装的影响。 这将为蛋白质自缔合提供分子水平的理解，并为设计阻止蛋白质聚集的抑制剂提供合理的基础。 这项工作还将通过表面上蛋白质的受控自组装来建立新型纳米材料的设计原则。